molting defective is required for ecdysone biosynthesis
molting defective is required for ecdysone biosynthesis
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DOI：
10.1016/j.ydbio.2005.01.023
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发表时间：
2005-04-15
影响因子：
2.7
通讯作者：
Cohen, SM
中科院分区：
文献类型：
--
作者：
Neubueser, D;Warren, JT;Cohen, SM
20-羟基蜕皮激素是半个世纪前发现的具有生物活性的主要昆虫甾体激素，但关于其生物合成及其活性仍有许多有待了解。20-羟基蜕皮激素控制许多生物过程，包括幼虫阶段之间的进展，进入蛹化和变态。已经鉴定了20-羟基丙酮产生所需的许多基因，包括编码介导生物合成后期步骤中的四个步骤的酶的那些基因。第二小类低蜕皮激素突变体不编码酶。在这里，我们报告一个这样的基因，我们称之为蜕皮缺陷，其致死表型的基础上确定。蜕皮缺陷型编码蜕皮激素生物合成所需的核锌指蛋白。(c)2005年爱思唯尔公司All rights reserved.
20-hydroxyecdysone was discovered as the major biologically active insect steroid hormone half a century ago, yet much remains to be learned about its biosynthesis and its activities. 20-hydroxyecdysone controls many biological processes, including progression between larval stages, entry to pupariation and metamorphosis. A number of genes required for 20-hydroxyccdysone production have been identified, including those encoding enzymes that mediate four of the late steps of biosynthesis. A second smaller group of low ecdysone mutants do not encode enzymes. Here, we report identification of one such gene, which we call molting defective, on the basis of its lethal phenotype. molting defective encodes a nuclear zinc finger protein required for ecdysone biosynthesis. (c) 2005 Elsevier Inc. All rights reserved.