Brain Organoids: Studying Human Brain Development and Diseases in a Dish.
Brain Organoids: Studying Human Brain Development and Diseases in a Dish.
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DOI：
10.1155/2021/5902824
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发表时间：
2021
影响因子：
4.3
通讯作者：
Wen Z
中科院分区：
文献类型：
--
作者：
Xu J;Wen Z
随着干细胞技术的快速发展，三维（3D）培养脑类器官的出现为研究人类神经发育和神经系统疾病开辟了新的途径。脑类器官是干细胞衍生的3D悬浮培养物，其自组装成具有细胞类型和细胞结构的有组织结构，重现发育中的大脑。近年来，脑类器官已被用于各个方面，从基础生物学研究到疾病建模和药物化合物的高通量筛选。本文综述了脑类器官技术的建立和发展、最新进展、转化应用以及存在的局限性和未来的发展方向。
With the rapid development of stem cell technology, the advent of three-dimensional (3D) cultured brain organoids has opened a new avenue for studying human neurodevelopment and neurological disorders. Brain organoids are stem-cell-derived 3D suspension cultures that self-assemble into an organized structure with cell types and cytoarchitectures recapitulating the developing brain. In recent years, brain organoids have been utilized in various aspects, ranging from basic biology studies, to disease modeling, and high-throughput screening of pharmaceutical compounds. In this review, we overview the establishment and development of brain organoid technology, its recent progress, and translational applications, as well as existing limitations and future directions.
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影响因子：
48
作者：
Bian S;Repic M;Guo Z;Kavirayani A;Burkard T;Bagley JA;Krauditsch C;Knoblich JA
通讯作者：
Knoblich JA
影响因子：
64.5
作者：
Andersen J;Revah O;Miura Y;Thom N;Amin ND;Kelley KW;Singh M;Chen X;Thete MV;Walczak EM;Vogel H;Fan HC;Paşca SP
通讯作者：
Paşca SP
影响因子：
64.8
作者：
Birey F;Andersen J;Makinson CD;Islam S;Wei W;Huber N;Fan HC;Metzler KRC;Panagiotakos G;Thom N;O'Rourke NA;Steinmetz LM;Bernstein JA;Hallmayer J;Huguenard JR;Paşca SP
通讯作者：
Paşca SP
影响因子：
5.3
作者：
Danjo, Teruko;Eiraku, Mototsugu;Sasai, Yoshiki
通讯作者：
Sasai, Yoshiki
影响因子：
16.2
作者：
Abud EM;Ramirez RN;Martinez ES;Healy LM;Nguyen CHH;Newman SA;Yeromin AV;Scarfone VM;Marsh SE;Fimbres C;Caraway CA;Fote GM;Madany AM;Agrawal A;Kayed R;Gylys KH;Cahalan MD;Cummings BJ;Antel JP;Mortazavi A;Carson MJ;Poon WW;Blurton-Jones M
通讯作者：
Blurton-Jones M