ELECTROPHYSIOLOGIC INDICATION OF DEFECTIVE INFORMATION-STORAGE IN CHILDHOOD AUTISM
ELECTROPHYSIOLOGIC INDICATION OF DEFECTIVE INFORMATION-STORAGE IN CHILDHOOD AUTISM
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DOI：
10.1016/0165-1781(79)90034-9
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发表时间：
1979-01-01
影响因子：
11.3
通讯作者：
VAUGHN, HG
中科院分区：
文献类型：
--
作者：
NOVICK, B;KURTZBERG, D;VAUGHN, HG
结合行为和电生理技术被用来测试的假设，即存储的信息是受损的儿童自闭症。对3名孤独症儿童和3名正常儿童进行了内源性事件相关电位的检测。所有的受试者都能够检测到刺激删除，但与刺激遗漏相关的皮层电位较小或不存在于自闭症受试者。这些结果与包括后顶叶皮层及其与中脑边缘颞叶皮层和海马的连接在内的系统内的功能障碍一致。
A combined behavioral and electrophysiological technique was used to test the hypothesis that storage of information is impaired in childhood autism. Endogenous event-related potentials associated with the random deletion of stimuli within a regular train of auditory or visual stimuli were examined in 3 autistic and 3 normal children. All subjects were able to detect the stimulus deletions, but cortical potentials associated with stimulus omissions were smaller or absent in the autistic subjects. These results are consistent with dysfunction within the system that includes posterior parietal cortex and its connections with the mesolimbic temporal cortex and hippocampus.