Enterovirus 71 in Taiwan
Enterovirus 71 in Taiwan
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DOI：
10.1016/s1875-9572(08)60023-6
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发表时间：
2008-08-01
影响因子：
2.1
通讯作者：
Chang, Luan-Yin
中科院分区：
文献类型：
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作者：
Chang, Luan-Yin
1998年在台湾爆发的肠病毒71型（EV 71）导致许多儿童死亡。在1998年爆发前进行的血清流行病学研究显示，流行前（1997年），成人和6岁以上儿童的EV 71血清阳性率约为60-70%。1980年至1981年进行的一项回顾性病例审查确定了16例与中枢神经系统受累有关的手足口病，其中2例在住院后不久死亡。在1998年的疫情中报告了405例重症病例和78例死亡，2000年至2002年仍报告了数十例EV 71致命病例。一个阶段为基础的管理策略，以减少死亡率，但大多数脑干脑炎心肺功能衰竭的幸存者有神经系统后遗症和认知功能受损。我们需要持续进行肠病毒71型的临床和实验室监测，以便及早实施控制和预防措施。EV 71特异性抗病毒疗法（一类新型咪唑烷酮类）的开发和疫苗的开发正在进行中。
The enterovirus 71 (EV71) outbreak in Taiwan in 1998 proved fatal in many children. A seroepidemiological study performed prior to the 1998 outbreak showed pre-epidemic (1997) EV71 seroprevalence rates to be about 60-70% in adults and children older than 6 years of age. A retrospective case review carried out from 1980-81 identified 16 cases of hand, foot and mouth disease associated with central nervous system involvement, two of whom died soon after hospitalization. There were 405 severe cases and 78 deaths reported in the 1998 epidemic, and dozens of fatal EV71 cases were still reported from 2000 to 2002. A stage-based management strategy was developed to reduce fatality, but most survivors of brainstem encephalitis with cardiopulmonary failure have neurologic sequelae and impaired cognition. Continuous clinical and laboratory surveillance of EV71 disease is required to enable earlier implementation of control and prevention measures. Development of EV71 specific antiviral therapy, a novel class of imidazolidinones, and development of a vaccine are ongoing.