Ultrahigh speed endoscopic optical coherence tomography using micromotor imaging catheter and VCSEL technology.
Ultrahigh speed endoscopic optical coherence tomography using micromotor imaging catheter and VCSEL technology.
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DOI：
10.1364/boe.4.001119
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发表时间：
2013-07-01
影响因子：
3.4
通讯作者：
Fujimoto JG
中科院分区：
文献类型：
--
作者：
Tsai TH;Potsaid B;Tao YK;Jayaraman V;Jiang J;Heim PJ;Kraus MF;Zhou C;Hornegger J;Mashimo H;Cable AE;Fujimoto JG
我们开发了一种基于微电机的微型导管，外径为3.2 mm，用于高速内窥镜扫描源光学相干断层扫描（OCT），使用垂直腔面发射激光器（VCSEL），轴向扫描速率为1 MHz。微电机可以在低于5V的驱动电压下以每秒数百帧的速度旋转微棱镜，以提供快速稳定的扫描，对导管的弯曲不敏感。侧视探头可以被拉回以获取覆盖样品上的大面积的三维（3D）数据集。VCSEL提供高轴向扫描速率以支持高帧速率操作下的密集采样。采用高速数据采集系统，以400 fps的帧速率对兔胃肠道进行了体内3D-OCT成像，并对人体结肠标本进行了离体成像，其轴向分辨率为8 μ m，横向分辨率为8 μm，组织深度范围为1.2 mm。
We developed a micromotor based miniature catheter with an outer diameter of 3.2 mm for ultrahigh speed endoscopic swept source optical coherence tomography (OCT) using a vertical cavity surface-emitting laser (VCSEL) at a 1 MHz axial scan rate. The micromotor can rotate a micro-prism at several hundred frames per second with less than 5 V drive voltage to provide fast and stable scanning, which is not sensitive to the bending of the catheter. The side-viewing probe can be pulled back to acquire a three-dimensional (3D) data set covering a large area on the specimen. The VCSEL provides a high axial scan rate to support dense sampling under high frame rate operation. Using a high speed data acquisition system, in vivo 3D-OCT imaging in the rabbit GI tract and ex vivo imaging of a human colon specimen with 8 μm axial resolution, 8 μm lateral resolution and 1.2 mm depth range in tissue at a frame rate of 400 fps was demonstrated.