Distribution volume ratio of serotonin and dopamine transporters in euthymic patients with a history of major depression - a dual-isotope SPECT study
Distribution volume ratio of serotonin and dopamine transporters in euthymic patients with a history of major depression - a dual-isotope SPECT study
复制标题
DOI：
10.1016/j.pscychresns.2010.09.004
复制
发表时间：
2010-12-30
影响因子：
2.3
通讯作者：
Chiu, Nan Tsing
中科院分区：
文献类型：
--
作者：
Hsieh, Pei Chun;Lee, I. Hui;Chiu, Nan Tsing
5-羟色胺转运体（SERT）和多巴胺转运体（DAT）水平在抑郁症患者中与健康对照组相比存在差异。本研究的目的是检查分布容积比（DVR）的SERT和DAT的药物和正常的患者与抑郁症的历史。受试者包括13名有抑郁症病史的患者和26名性别和年龄匹配的健康对照者。抑郁的心境正常状态定义为汉密尔顿抑郁评定量表评分为7分或更低。分别以[I-123] 2-（（2-（（二甲氨基）甲基）苯基）硫代）-5-碘苯胺（ADAM）和[Tc-99 m] TRODAT-1为配体，用SPEC近似计算了SERT和DAT的DVR。健康受试者和有抑郁症病史的正常受试者之间SERT或DAT的DVR没有显著差异;因此，SERT和DAT DVR可能不是抑郁症患者的特质标记，这有助于我们更多地了解抑郁症的病理生理学。(C)2010爱思唯尔爱尔兰有限公司版权所有。
Serotonin transporter (SERT) and dopamine transporter (DAT) levels differ in patients with major depression who are in a depressed state in comparison with healthy controls. The aim of this study was to examine the distribution volume ratios (DVRs) of SERT and DAT in drug-free and euthymic patients with a history of major depression. Subjects comprised 13 patients with a history of major depression and 26 sex- and age-matched healthy controls. The euthymic state of depression was defined as a score of 7 or less on the Hamilton Depression Rating Scale. The DVRs of SERT and DAT were approximated using SPEC, with [I-123] 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM) and [Tc-99m] TRODAT-1 as the ligands, respectively. There were no significant differences in the DVRs of SERT or DAT between healthy subjects and euthymic patients with a history of major depression; hence, the SERT and DAT DVRs may not therefore be trait markers for patients with major depression, which helps us to understand more about the pathophysiology of depression. (C) 2010 Elsevier Ireland Ltd. All rights reserved.