Tea tree oil reduces the swelling associated with the efferent phase of a contact hypersensitivity response
Tea tree oil reduces the swelling associated with the efferent phase of a contact hypersensitivity response
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DOI：
10.1007/pl00000299
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发表时间：
2002-05-01
影响因子：
6.7
通讯作者：
Hart, PH
中科院分区：
文献类型：
--
作者：
Brand, C;Grimbaldeston, MA;Hart, PH
目的：观察茶树油(TTO)的体内抗炎活性。方法：用化学半抗原三硝基氯苯致敏小鼠腹部皮肤，7d后以相同的半抗原攻击(或再次暴露)小鼠背部皮肤。结果：TTO在攻击前30min或攻击后7h内与半抗原攻击相同的背部部位应用TTO可明显减轻小鼠皮肤肿胀，但不能减少炎症细胞的涌入。TTO不能抑制肿瘤坏死因子α诱导的人脐静脉内皮细胞E-选择素的表达，这一发现得到了支持。结论：外用TTO，尤其是TTO成分、松油烯-4-醇和α-松油醇，可调节接触性超敏反应传出相引起的水肿。
Objective: To examine the anti-inflammatory activities of tea tree oil (TTO) in vivo.Methods: Mice were sensitized to a chemical hapten, trinitrochlorobenzene, on their ventral skin and 7 days later challenged (or re-exposed) on their dorsal skin with the same hapten.Results: TTO applied 30 min before or up to 7 h after to the same dorsal site as hapten challenge caused a significant reduction in skin swelling after 24 h. TTO reduced oedema but not the influx of inflammatory cells. This finding was supported by the inability of TTO to suppress TNFalpha-induced E-selectin expression by human umbilical vein endothelial cells. TTO did not suppress irritant- or ultraviolet B-induced oedema.Conclusion: Topical TTO, specifically the TTO components, terpinen-4-ol and alpha-terpineol can regulate the oedema associated with the efferent phase of a contact hypersensitivity response.