B cells: new ways to inhibit their function in rheumatoid arthritis.
B cells: new ways to inhibit their function in rheumatoid arthritis.
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B 细胞：抑制其在类风湿性关节炎中的功能的新方法。
DOI：
10.1007/s11926-004-0010-7
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发表时间：
2004
影响因子：
5
通讯作者：
Carter,RobertH
中科院分区：
文献类型：
--
作者：
Carter,RobertH
B细胞耗竭在自身免疫性疾病中的明显功效增加了靶向B细胞的兴趣。下一代疗法的一个目标是开发阻断B细胞活化并保护保持B细胞记忆的静息非自身免疫细胞的治疗方法。要做到这一点，人们需要了解B细胞是如何被激活的，以及哪些受体和细胞内信号通路调节这一过程。本文将总结B细胞活化途径，并说明如何在开发类风湿关节炎的新疗法中靶向这些途径。
The apparent efficacy of B-cell depletion in autoimmune diseases has increased interest in targeting B cells. One goal of next generation therapies is to develop treatments that block B-cell activation and preserve resting nonautoimmune cells that maintain B cell memory. To do so, one needs to understand how B cells are activated and what receptors and intracellular signaling pathways regulate this process. This paper will summarize B-cell activation pathways and illustrate how these are being targeted in the development of new treatments for rheumatoid arthritis.