The molecular basis of bacterial-insect symbiosis.
The molecular basis of bacterial-insect symbiosis.
复制标题
DOI：
10.1016/j.jmb.2014.04.005
复制
发表时间：
2014-11-25
影响因子：
5.6
通讯作者：
Douglas AE
中科院分区：
文献类型：
--
作者：
Douglas AE
昆虫提供了实验上易于处理和成本效益的模型系统，以研究动物-细菌相互作用的分子基础。最近的研究揭示了昆虫先天免疫系统的核心作用，特别是抗微生物肽和活性氧物质，在调节各种昆虫，包括果蝇和蚊子伊蚊和按蚊的微生物群落的丰度和组成。然而，免疫系统和微生物群之间的相互作用是双向的，有证据表明，常驻微生物群的成员可以促进免疫功能，通过激活免疫效应子和产生毒素来赋予对病原体和寄生虫的抵抗力。细菌之间的拮抗和互利相互作用也被认为是微生物群组成的决定因素，包括排除病原体，但分子机制在很大程度上是未知的。一些细菌通过提供特定的营养物（例如B族维生素、必需氨基酸）和调节昆虫营养感测和信号传导途径（例如胰岛素信号传导）对昆虫营养至关重要，所述昆虫营养感测和信号传导途径调节营养分配，特别是对脂质和其他能量储备。未来研究的一个关键挑战是确定特定细菌效应器和动物受体之间的分子相互作用，并确定这些相互作用如何转化为宿主中微生物依赖的信号传导，代谢和免疫功能。
Insects provide experimentally tractable and cost-effective model systems to investigate the molecular basis of animal-bacterial interactions. Recent research is revealing the central role of the insect innate immune system, especially anti-microbial peptides and reactive oxygen species, in regulating the abundance and composition of the microbiota in various insects, including Drosophila and the mosquitoes Aedes and Anopheles. Interactions between the immune system and microbiota are, however, bidirectional with evidence that members of the resident microbiota can promote immune function, conferring resistance to pathogens and parasites by both activation of immune effectors and production of toxins. Antagonistic and mutualistic interactions among bacteria have also been implicated as determinants of the microbiota composition, including exclusion of pathogens, but the molecular mechanisms are largely unknown. Some bacteria are crucial for insect nutrition, through provisioning of specific nutrients (e.g. B vitamins, essential amino acids) and modulation of the insect nutritional sensing and signaling pathways (e.g. insulin signaling) that regulate nutrient allocation, especially to lipid and other energy reserves. A key challenge for future research is to identify the molecular interaction between specific bacterial effectors and animal receptors, and to determine how these interactions translate into microbiota-dependent signaling, metabolism and immune function in the host.
登录
查看更多内容
影响因子：
11.8
作者：
Ha, Eun-Mi;Lee, Kyung-Ah;Lee, Won-Jae
通讯作者：
Lee, Won-Jae
影响因子：
4.4
作者：
Degnan, Patrick H.;Moran, Nancy A.
通讯作者：
Moran, Nancy A.
影响因子：
6.7
作者：
Caragata EP;Rancès E;Hedges LM;Gofton AW;Johnson KN;O'Neill SL;McGraw EA
通讯作者：
McGraw EA
影响因子：
5.4
作者：
Goodacre SL;Martin OY;Bonte D;Hutchings L;Woolley C;Ibrahim K;George Thomas C;Hewitt GM
通讯作者：
Hewitt GM
影响因子：
11.8
作者：
Katona, Peter;Katona-Apte, Judit
通讯作者：
Katona-Apte, Judit