Functional strains and cortical bone adaptation: epigenetic assurance of skeletal integrity.
Functional strains and cortical bone adaptation: epigenetic assurance of skeletal integrity.
复制标题
功能应变和皮质骨适应：骨骼完整性的表观遗传保证。
DOI：
10.1016/0021-9290(90)90040-a
复制
发表时间：
1990
影响因子：
2.4
通讯作者：
Bain,SD
中科院分区：
文献类型：
--
作者：
Rubin,CT;McLeod,KJ;Bain,SD
骨骼承受极端身体活动的能力在很大程度上是通过其感知和响应机械环境中微小变化的能力来实现的。由功能活动产生的应变将代表一种有效的表观遗传参数，骨细胞群体可以通过该参数评估骨骼的结构有效性，并随后使用该信息来影响其形态。然而，与我们对沃尔夫定律的正常解释相反，最小化应变似乎不是适应的最高目标，而是骨骼形态与功能活动相互作用，产生某种可能在细胞学上有益的应变类型。（B）在组织水平上，应变环境的骨调节参数;和（c）在细胞水平上，物理信息转化为适应性反应的机制。只有当我们了解正常骨骼中组织适应的机制和目标时，我们才能增强对功能性影响骨骼病变（例如骨质减少，骨折）的观点和治疗。
The skeleton's ability to withstand the extremes of physical activity is achieved in large part by its capacity to perceive and respond to small changes in its mechanical environment. Strains generated by functional activity would represent an efficient, epigenetic parameter by which the bone cell population could assess the skeleton's structural effectiveness, and subsequently use this information to influence its morphology. However, contrary to our normal interpretation of Wolff's Law, minimizing strain does not appear to be the paramount goal of adaptation, but rather skeletal morphology interacts with functional activity to generate a certain, perhaps cytologically beneficial, type of strain.Three sections are used to address the epigenetic impact on bone morphology: (a) at the level of the organ, the strains generated by functional activity; (b) at the level of the tissue, osteoregulatory parameters of the strain environment; and (c) at the level of the cell, the mechanisms by which physical information is translated to an adaptive response. Only when we understand the mechanisms and objectives of tissue adaptation in the normal skeleton can our perspective and treatment of functionally influenced skeletal pathologies (e.g. osteopenias, fractures) be enhanced.