LIVER BIOPSY: IMPORTANCE OF SPECIMEN SIZE IN THE DIAGNOSIS AND STAGING OF CHRONIC VIRAL HEPATITIS.
LIVER BIOPSY: IMPORTANCE OF SPECIMEN SIZE IN THE DIAGNOSIS AND STAGING OF CHRONIC VIRAL HEPATITIS.
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DOI：
10.1590/s1678-9946201658010
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发表时间：
2016
影响因子：
1.9
通讯作者：
Mattos AA
中科院分区：
文献类型：
--
作者：
Coral GP;Antunes AD;Serafini AP;Araujo FB;Mattos AA
肝活检是慢性病毒性肝炎分级和分期的金标准方法，但活检标本的最佳大小仍存在争议。本研究的目的是评估肝标本的质量(门静脉数量)，并评估门静脉数量在慢性肝炎分期中的影响。对2009-2010年间连续468例丙型肝炎和乙肝病毒感染者的肝活检进行了评估。碎片长度<10 mm者43例(9.3%)，10~14 mm者114例(24.3%)，≥15 mm者311例(64.4%)，其中≥20 mm者39例(8.3%)。≥15 mm组和≤15 mm组的平均门静脉直径分别为13.5±4.7和11.4±5.0(P=0.002)。门静脉少于11条的病例与F3相关，11条或11条以上的病例与F2相关(p=0.001)。这项研究证明了肝活检的良好质量，以及断片的宏观大小与门静脉的数量之间的关系。
Liver biopsy is the gold standard method for the grading and staging of chronic viral hepatitis, but optimal biopsy specimen size remains controversial. The aim of this study was to evaluate the quality of liver specimen (number of portal tracts) and to evaluate the impact of the number of portal tracts in the staging of chronic hepatitis. 468 liver biopsies from consecutive patients with hepatitis C virus and hepatitis B virus infection from 2009 to 2010 were evaluated. The length of fragment was less than 10 mm in 43 cases (9.3%), between 10 and 14 mm in 114 (24.3%), and ≥ 15 mm in 311 (64.4%); of these, in 39 (8.3%) cases were ≥ 20 mm. The mean representation of portal tracts was 17.6 ± 2.1 (5-40); in specimens ≥ 15 mm the mean portal tract was 13.5 ± 4.7 and in cases ≤ 15 mm was 11.4 ± 5.0 (p = 0.002). Cases with less than 11 portal tracts were associated with F3, and cases with 11 or more portal tracts with F2 (p = 0.001). this study demonstrated the good quality of liver biopsy and a relationship between the macroscopic size of the fragment and the number of portal tracts.