Immune signaling in sex-specific neural and behavioral development: Adolescent opportunity.
Immune signaling in sex-specific neural and behavioral development: Adolescent opportunity.
复制标题
DOI：
10.1016/j.conb.2022.102647
复制
发表时间：
2022-12
影响因子：
5.7
通讯作者：
中科院分区：
文献类型：
--
作者：
神经和行为发育的性别差异是理解神经发育，心理健康和神经退行性疾病不可或缺的。大部分文献都集中在产前晚期和产后早期，将其作为建立性别特异性发育轨迹的关键时刻，现在数据清楚地表明，免疫信号在建立生命早期性别差异方面发挥着核心作用。青春期是另一个出现性别差异的发育时期。然而，我们对免疫信号如何在青春期建立性别差异中发挥作用知之甚少。在此，我们回顾了青春期性别差异的定义明确的例子，然后调查文献，推测免疫信号可能在定义性别特异性青少年结果中发挥作用。我们讨论了文献中的开放性问题，并提出了实验设计原则，可能有助于更好地了解青少年的神经发育。
Sex differences in neural and behavioral development are integral to understanding neurodevelopmental, mental health, and neurodegenerative disorders. Much of the literature has focused on late prenatal and early postnatal life as a critical juncture for establishing sex-specific developmental trajectories, and data are now clear that immune signaling plays a central role in establishing sex differences early in life. Adolescence is another developmental period during which sex differences arise. However, we know far less about how immune signaling plays a role in establishing sex differences during adolescence. Herein, we review well-defined examples of sex differences during adolescence, and then survey the literature to speculate how immune signaling might be playing a role in defining sex-specific adolescent outcomes. We discuss open questions in the literature and propose experimental design tenets that may assist in better understanding adolescent neurodevelopment.