ABC transporters and their role in nucleoside and nucleotide drug resistance.
ABC transporters and their role in nucleoside and nucleotide drug resistance.
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DOI：
10.1016/j.bcp.2011.12.042
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发表时间：
2012-04-15
影响因子：
5.8
通讯作者：
Schuetz, John D.
中科院分区：
文献类型：
--
作者：
Fukuda, Yu;Schuetz, John D.
ATP结合盒（ABC）转运蛋白赋予针对广泛的化疗剂（包括核苷和核苷酸类药物）的耐药性。虽然核苷类药物已用于治疗实体和血液恶性肿瘤以及病毒和自身免疫性疾病多年，但ABC转运蛋白的潜在贡献最近才被认识到。这种忽视可能是因为核苷衍生物的活化需要初始载体介导的摄取步骤，然后通过核苷激酶磷酸化，并且摄取或激酶活化的缺陷被认为是核苷耐药的主要机制。然而，最近的研究表明，ABCC转运蛋白亚家族的成员减少单磷酸化核苷药物的细胞内浓度。除了ABCC亚家族成员之外，ABCG 2已显示转运核苷药物和临床相关核苷药物的核苷-单磷酸衍生物，例如阿糖胞苷、克拉屈滨和氯法拉滨。这篇综述将讨论ABC转运蛋白以及它们如何与其他影响核苷类药物疗效的过程相互作用。
ATP-binding cassette (ABC) transporters confer drug resistance against a wide range of chemotherapeutic agents, including nucleoside and nucleotide based drugs. While nucleoside based drugs have been used for many years in the treatment of solid and hematological malignancies as well as viral and autoimmune diseases, the potential contribution of ABC transporters has only recently been recognized. This neglect is likely because activation of nucleoside derivatives require an initial carrier-mediated uptake step followed by phosphorylation by nucleoside kinases, and defects in uptake or kinase activation were considered the primary mechanisms of nucleoside drug resistance. However, recent studies demonstrate that members of the ABCC transporter subfamily reduce the intracellular concentration of monophosphorylated nucleoside drugs. In addition to the ABCC subfamily members, ABCG2 has been shown to transport nucleoside drugs and nucleoside-monophosphate derivatives of clinically relevant nucleoside drugs such as cytarabine, cladribine, and clofarabine to name a few. This review will discuss ABC transporters and how they interact with other processes affecting the efficacy of nucleoside based drugs.
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影响因子：
11.2
作者：
Cai, Jie;Damaraju, Vijaya L.;Gros, Philippe
通讯作者：
Gros, Philippe
影响因子：
45.3
作者：
CAPIZZI, RL;YANG, JL;CHENG, YC
通讯作者：
CHENG, YC
影响因子：
11.4
作者：
BERKOWER, C;MICHAELIS, S
通讯作者：
MICHAELIS, S
DOI：
10.1126/science.1168750
发表时间：
2009-03-27
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Aller SG;Yu J;Ward A;Weng Y;Chittaboina S;Zhuo R;Harrell PM;Trinh YT;Zhang Q;Urbatsch IL;Chang G
通讯作者：
Chang G
影响因子：
64.8
作者：
Dawson, Roger J. P.;Locher, Kaspar P.
通讯作者：
Locher, Kaspar P.