MALIGNANT ANGIOENDOTHELIOMA OF THE SKIN
MALIGNANT ANGIOENDOTHELIOMA OF THE SKIN
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DOI：
10.1111/j.1365-2133.1964.tb13970.x
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发表时间：
1964-01-01
影响因子：
10.3
通讯作者：
JONES, EW
中科院分区：
文献类型：
--
作者：
JONES, EW
仅有的两种发生在皮肤上的恶性血管肿瘤有任何频率的报道是卡波西特发性出血肉瘤和斯图尔特和特里夫斯肿瘤，后者是乳房切除术后淋巴水肿的并发症，发生在手臂上。Willis（1960）认为所有“真正的恶性血管母细胞肿瘤”都是极其罕见的。他和其他作者（Stout, 1943; Kinkade， 1949和Landing and Farber， 1956）强调了正确组织学诊断的困难。兰迪(1)58)在世界文献中只能找到117例可接受的血管肉瘤和血管内皮瘤病例。只有18个来源于皮肤和皮下组织。本文报告9例发生于面部和头皮的恶性血管内皮瘤，均发生于老年患者。9名患者中有7名已经死亡，3名正在进行尸检。这些肿瘤表现出通过皮肤局部浸润扩散的显著能力，因此在7个致命病例中，面部和头皮的大部分，甚至颈部的部分，在晚期受到影响。组织学上肿瘤是独特的，被故意描述为恶性血管内皮瘤而不是血管肉瘤。后一术语已应用于血管形成性肉瘤，其表现出许多不同的组织学模式；这与恶性血管内皮瘤所表现出的恒定且几乎特定的特征形成对比。但必须有一个附带条件，即当肿瘤变得未分化时，这种特异性往往会丧失。血管内皮瘤的组织发生可能是成熟内皮细胞的恶性转化。另一方面血管肉瘤的多形性特点。其中内皮细胞增殖可能只是一个组成部分，提示起源于多能性的“胚细胞”。
THE only two malignant vascular tumours arising in the skin that have been reported with any frequency are Kaposi's idiopathic haemorrhagie sarcoma and the Stewart and Treves tumour which develops in arms as a complication of post-mastectomy lymphoedema. Willis (1060) believes that all•• true malignant angioblastic neoplasms" are extremely rare. He and other authors (Stout, 1943; Kinkade, 1949 and Landing and Farber. 1956), emphasize the difficulty of correct histological diagnosis. Landells (1!) 58) could only find one hundred and seventeen acceptable cases of angiosarcoma and haemangioendothelioma in the world literature. Only eighteen originated in the skin and subcutaneous tissue.The main purpose of this paper is to report nine malignant angioendothcliomas of the face and scalp, all of which developed in elderly patients. Seven of the nine patients have died, three coming to necropsy. These tumours showed a remarkable ability to spread by local infiltration through the skin, so that in the seven fatal cases the greater part of the face and scalp, and even parts of the neck, were affected in the terminal stages. Histologically the tumours were distinctive and are dehberately described as malignant angiocndotheliomas rather than as angiosarcomas. The latter term has been applied to vasoformative sarcomas which show many varied histological patterns; this is in contrast with the constant and almost sjiecific features shown by malignant angioendotheliomas. But the proviso must be made that such a specificity tends to be lost as the tumour becomes undifFerentiated. The probable histogenesis of the angioendotheliomas is by a malignant transformation of mature endothelial cells. On the other hand the pleomorphic features of angiosarcoma. of which endothelial jjroliferation may be only one component, suggest an origin from a pluripotential'" blast cell".