IL-7 treatment supports CD8+ mucosa-associated invariant T-cell restoration in HIV-1-infected patients on antiretroviral therapy.
IL-7 treatment supports CD8+ mucosa-associated invariant T-cell restoration in HIV-1-infected patients on antiretroviral therapy.
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DOI：
10.1097/qad.0000000000001760
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发表时间：
2018-03-27
期刊：
影响因子：
--
通讯作者：
Sereti I
中科院分区：
文献类型：
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作者：
Sortino O;Richards E;Dias J;Leeansyah E;Sandberg JK;Sereti I
慢性HIV-1感染与粘膜相关不变T （MAIT）细胞的低频率和功能损伤有关。我们评估了IL-7治疗在抗逆转录病毒治疗慢性HIV-1感染者外周血中恢复MAIT细胞的效果。IL-7导致MAIT细胞的相对和绝对水平升高，这种扩增主要发生在CD8+亚群中。这些结果表明，IL-7可能代表了慢性HIV-1感染中MAIT细胞恢复的治疗干预。
Chronic HIV-1 infection is associated with lower frequencies and functional impairment of mucosa-associated invariant T (MAIT) cells. We evaluated IL-7 treatment to restore MAIT cells in peripheral blood of chronically HIV-1 infected individuals on ART. IL-7 led to increased relative and absolute levels of MAIT cells and this expansion occurred primarily in the CD8+ subset. These results suggest that IL-7 may represent a therapeutic intervention for the restoration of MAIT cells in chronic HIV-1 infection.