Core-shell structured assembly strategy of naphthalene anhydride derivatives and MPS-modified mesoporous SiO2 with temperature-responsive property for controlled drug delivery with strong fluorescence
Core-shell structured assembly strategy of naphthalene anhydride derivatives and MPS-modified mesoporous SiO2 with temperature-responsive property for controlled drug delivery with strong fluorescence
复制标题
萘酐衍生物和具有温度响应特性的 MPS 改性介孔 SiO2 的核壳结构组装策略，用于强荧光控制药物递送
DOI：
10.1080/00914037.2020.1765363
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发表时间：
2020-05-19
影响因子：
3.2
通讯作者：
Wu, Xia
中科院分区：
文献类型：
--
作者：
Liu, Chang;Sheng, Mengdi;Wu, Xia
摘要以双峰介孔二氧化硅材料(BMMS)为核，聚(N-异丙基丙烯酰胺)-共聚(丙烯酸)为壳，采用自组装方法合成了具有核壳结构的荧光温敏介孔材料。特别是以2-[3-(三乙氧基硅基)丙基-1H-苯并苯][去]异喹啉-1，3(2H)-二酮(PID)为荧光分子，通过一锅(掺杂)或两步(接枝)的方法将其引入到BMMS中。以布洛芬为模型药物，以PID掺杂的P@BMMS及其接枝的P@BMMS为载体，制备的药物释放性能表现出较强的荧光特性和温度响应行为。这些结果表明，所制备的荧光纳米复合材料有望成为潜在的药物载体。图形摘要
Abstract The fluorescent temperature-sensitive mesoporous materials with core-shell structured feature were synthesized through self-assembly method, in which, bimodal mesoporous SiO2 materials (BMMs) were used as a core and poly(N-isopropyl acryl-acrylamide)-co-poly(acrylic acid) as a shell. Especially, the 2-[3-(triethoxysilyl) propyl-1H-Benz][de]isoquinoline-1,3(2H)-dione (PID) as fluorescent molecule was cooperated into the BMMs by one-pot (doped) or two-step (grafted) methods. Using ibuprofen as a model drug, and the PID-doped P@BMMs and PID-grafted P@BMMs as the carriers, the drug releasing performances show the strong fluorescent properties and temperature-responsive behaviors. These results suggest that the prepared fluorescent nanocomposites should be a promise drug carrier for a potential drug delivery. Graphical Abstract