Taxol: a history of pharmaceutical development and current pharmaceutical concerns.
Taxol: a history of pharmaceutical development and current pharmaceutical concerns.
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发表时间：
1993
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通讯作者：
Adamson Jd;Flora Kp;Goldspiel Br;Wilson Jw;S. Arbuck;R. Finley
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作者：
Adamson Jd;Flora Kp;Goldspiel Br;Wilson Jw;S. Arbuck;R. Finley
紫杉醇是一种独特的二萜类抗癌化合物，来源于短叶红豆杉（太平洋紫杉）树的树皮，通过一种新的作用机制诱导细胞毒性。作为一种抗微管剂，紫杉醇促进微管蛋白聚合物的形成和稳定，不像其他抗癌剂诱导微管分解。由于其水溶性差，紫杉醇被配制成溶于50% Cremophor EL和50%无水乙醇的溶液，USP。紫杉醇制剂中使用的Cremophor EL和无水乙醇载体为其制备和给药带来了一些有趣的挑战。讨论了与紫杉醇的制备和给药相关的药学问题。
Taxol, a unique diterpene anticancer compound derived from the bark of the Taxus brevifolia (Pacific yew) tree, induces cytotoxicity by a novel mechanism of action. An antimicrotubule agent, Taxol promotes the formation and stabilization of the tubulin polymer unlike other anticancer agents that induce microtubule disassembly. Because of its poor aqueous solubility, Taxol is formulated as a solution in 50% Cremophor EL and 50% dehydrated alcohol, USP. The Cremophor EL and dehydrated alcohol vehicle used in the formulation of Taxol creates some interesting challenges for its preparation and administration. The pharmaceutical concerns associated with the preparation and administration of Taxol are discussed.