High Brightness, Highly Directional Organic Light-Emitting Diodes as Light Sources for Future Light-Amplifying Prosthetics in the Optogenetic Management of Vision Loss
High Brightness, Highly Directional Organic Light-Emitting Diodes as Light Sources for Future Light-Amplifying Prosthetics in the Optogenetic Management of Vision Loss
复制标题
高亮度、高定向有机发光二极管作为未来光放大假肢在视力丧失光遗传学治疗中的光源
DOI：
10.1002/adom.202200877
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发表时间：
2022
影响因子：
9
通讯作者：
Hillebrandt S
中科院分区：
文献类型：
--
作者：
Hillebrandt S
用光敏通道视紫红质转导的视网膜细胞的光遗传学控制可以使视力丧失患者的视觉恢复。然而，需要比环境光条件高几个数量级的光强度来实现稳健的细胞激活。相对庞大的可穿戴光放大器目前用于在合适的波长（例如，对于通道视紫红质，600 nm）。在这里，开发了具有高度定向发射的超高亮度有机发光二极管（OLED），最终目标是从紧凑的设备并行提供数千个视网膜细胞的高分辨率光遗传学控制。该橙子磷光OLED使用掺杂的电荷传输层，在600 nm处产生窄带发射峰，在15 V正向偏压下实现684 000 cd m-2的亮度。此外，串联堆叠OLED具有1 152 000 cd m-2的亮度和两倍的量子效率，这大大降低了这些器件中的电应力和热应力。在基因修饰的视网膜细胞中触发强大神经元放电所需的光子通量下，当使用散热和实际占空比（12.5 Hz时为20%）时，串联堆叠OLED显示出800 h的大幅改善的半亮度寿命。
Optogenetic control of retinal cells transduced with light‐sensitive channelrhodopsins can enable restoration of visual perception in patients with vision loss. However, a light intensity orders of magnitude higher than ambient light conditions is required to achieve robust cell activation. Relatively bulky wearable light amplifiers are currently used to deliver sufficient photon flux (>1016photons/cm2/s in a ±10° emission cone) at a suitable wavelength (e.g., 600 nm for channelrhodopsin ChrimsonR). Here, ultrahigh brightness organic light‐emitting diodes (OLEDs) with highly directional emission are developed, with the ultimate aim of providing high‐resolution optogenetic control of thousands of retinal cells in parallel from a compact device. The orange‐emitting phosphorescent OLEDs use doped charge transport layers, generate narrowband emission peaking at 600 nm, and achieve a luminance of 684 000 cd m–2at 15 V forward bias. In addition, tandem‐stack OLEDs with a luminance of 1 152 000 cd m–2and doubled quantum efficiency are demonstrated, which greatly reduces electrical and thermal stress in these devices. At the photon flux required to trigger robust neuron firing in genetically modified retinal cells and when using heat sinking and realistic duty cycles (20% at 12.5 Hz), the tandem‐stack OLEDs therefore show a greatly improved half‐brightness lifetime of 800 h.