Absence of detectable HIV-1 viremia after treatment cessation in an infant.
Absence of detectable HIV-1 viremia after treatment cessation in an infant.
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DOI：
10.1056/nejmoa1302976
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发表时间：
2013-11-07
期刊：
影响因子：
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通讯作者：
Luzuriaga K
中科院分区：
文献类型：
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作者：
Persaud D;Gay H;Ziemniak C;Chen YH;Piatak M Jr;Chun TW;Strain M;Richman D;Luzuriaga K
一名感染人类免疫缺陷病毒1型(HIV-1)的妇女所生的婴儿，由于高风险暴露，在出生30小时后开始接受抗逆转录病毒治疗。当重复试验中检测到的HIV-1DNA和RNA符合感染的标准诊断标准时，继续进行ART。在停止治疗后(当孩子18个月大的时候)，通过临床测试评估的血浆HIV-1RNA、外周血单核细胞中的前病毒DNA和HIV-1抗体的水平在孩子30个月大时仍然检测不到。这一案例表明，婴儿早期接受抗逆转录病毒治疗可能会改变HIV-1感染的确立和长期持续。
An infant born to a woman with human immunodeficiency virus type 1 (HIV-1) infection began receiving antiretroviral therapy (ART) 30 hours after birth owing to high-risk exposure. ART was continued when detection of HIV-1 DNA and RNA on repeat testing met the standard diagnostic criteria for infection. After therapy was discontinued (when the child was 18 months of age), levels of plasma HIV-1 RNA, proviral DNA in peripheral-blood mononuclear cells, and HIV-1 antibodies, as assessed by means of clinical assays, remained undetectable in the child through 30 months of age. This case suggests that very early ART in infants may alter the establishment and long-term persistence of HIV-1 infection.