MICROTUBULES AND FILAMENTS IN THE AXONS AND ASTROCYTES OF EARLY POSTNATAL RAT OPTIC NERVES
MICROTUBULES AND FILAMENTS IN THE AXONS AND ASTROCYTES OF EARLY POSTNATAL RAT OPTIC NERVES
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产后早期大鼠视神经轴突和星形胶质细胞中的微管和细丝
DOI：
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发表时间：
1967
影响因子：
7.8
通讯作者：
J. E. Vaughn
中科院分区：
文献类型：
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作者：
A. Peters;J. E. Vaughn
在大鼠视神经出生后早期发育过程中，研究了成熟轴突和星形胶质细胞胞质内微管和细丝数量的变化。在出生时，所有的轴突都是无髓鞘的;大多数直径为0.2-0.3 µ，含有4-10个微管。直到出生后约5天，神经丝才以任何频率出现，此时它们以单独的组出现，每组包含4-12个。随后，每组的神经丝分散，使它们在成熟轴突中变得更均匀分布。发育中的星形胶质细胞表现出类似但更戏剧性的变化。大多数星形胶质细胞的突起在出生时只含有微管，但在成熟过程中，丝开始出现在越来越多的微管变得不常见。这个过程一直持续到成熟的纤维状星形胶质细胞中，细胞质中充满了细丝，微管很少。这些观察结果表明，轴突和星形胶质细胞内的细丝可能是通过微管的分解形成的。
Changes in the population of microtubules and filaments within the cytoplasm of maturing axons and astrocytes have been studied during the early postnatal development of rat optic nerves. At birth, all of the axons are unmyelinated; most have a diameter of 0.2–0.3 µ and contain 4–10 microtubules. Neurofilaments do not occur with any frequency until about 5 days postnatal when they appear as individual groups, each containing 4–12. Subsequently, the neurofilaments of each group disperse so that they become more evenly distributed in mature axons. Developing astrocytes show similar but rather more dramatic changes. Most astrocytic processes contain only microtubules at birth, but during maturation filaments begin to appear in increasing numbers while microtubules become less common. This process continues until, in the mature fibrous astrocytes, filaments pack the cytoplasm and microtubules are rare. These observations suggest that the filaments within axons and astrocytes may be formed by the breakdown of microtubules.