Similarities between the pathogenesis of and immunity to diphtheria and pertussis: the complex nature of serum antitoxin-induced immunity to these two diseases.
Similarities between the pathogenesis of and immunity to diphtheria and pertussis: the complex nature of serum antitoxin-induced immunity to these two diseases.
复制标题
白喉和百日咳的发病机制和免疫之间的相似之处：血清抗毒素诱导的对这两种疾病的免疫的复杂性。
DOI：
10.1086/515060
复制
发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Schneerson,R
中科院分区：
文献类型：
--
作者：
Schneerson,R
尽管有动物研究、血清流行病学调查和对照临床试验的数据，但对血清IgG中和抗体（抗毒素）赋予百日咳免疫力的怀疑仍然存在。这在很大程度上是由于缺乏“保护性”抗毒素水平。对百日咳和白喉的发病机制和免疫之间的相似性的研究为这种困境提供了解释。与百日咳一样，白喉类毒素疫苗接种在个体基础上仅赋予约70%的免疫力，具有保护水平的抗毒素的个体可能感染白喉，并且约50%的整个人口，特别是成年人，具有低于保护水平的抗毒素。白喉类毒素疫苗接种后，白喉几乎消失了，这阻断了白喉棒状杆菌的传播，从而使病原体减少到几乎检测不到的水平。我们假设白喉类毒素诱导的个体和社区免疫与百日咳和百日咳类毒素相似。
Despite data from animal studies, seroepidemiological surveys, and controlled clinical trials, skepticism persists about immunity to pertussis conferred by serum IgG neutralizing antibodies (antitoxin). This is largely prompted by the absence of a “protective” level of antitoxin. Examination of the similarities between the pathogenesis and immunity to pertussis and diphtheria provides an explanation for this dilemma. As with pertussis, diphtheria toxoid vaccination confers only ∼70% immunity on an individual basis, individuals with protective levels of antitoxin may contract diphtheria, and about 50% of the entire population, especially adults, have less than protective levels of antitoxin. The virtual disappearance of diphtheria followed vaccination of the entire population with diphtheria toxoid, which blocked transmission of toxigenicCorynebacterium diphtheriaeand thus reduced the pathogen to almost undetectable levels. The individual and community-based immunity induced by diphtheria toxoid, we hypothesize, is similar to that of pertussis and pertussis toxoid.