CYTOTOXIC T-CELL MEMORY WITHOUT ANTIGEN
CYTOTOXIC T-CELL MEMORY WITHOUT ANTIGEN
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DOI：
10.1038/369648a0
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发表时间：
1994-06-23
期刊：
影响因子：
64.8
通讯作者：
AHMED, R
中科院分区：
文献类型：
--
作者：
LAU, LL;JAMIESON, BD;AHMED, R
记忆是免疫系统的一个标志，自从其被认知以来，人们对理解免疫是如何维持的就有着极大的兴趣（1 - 5）。当前的模型是长期记忆依赖于持续的抗原刺激（6 - 11）。我们在此报告的结果对这一观点提出了挑战，并提供了证据表明抗原对于维持CD8（+）T细胞记忆不是必需的。我们表明，在没有致敏抗原的情况下，记忆性CD8（+）细胞毒性T淋巴细胞会无限期地持续存在，保留记忆表型（CD44（高）），并提供针对病毒攻击的保护。这些发现提示我们需要重新评估当前关于维持免疫所涉及机制的思考，并且对设计有效的疫苗接种策略具有影响。
Memory is a hallmark of the immune system and ever since its recognition there has been considerable interest in understanding how immunity is maintained(1-5). The current model is that long-term memory is dependent on persistent antigenic stimulation(6-11). We report here results that challenge this view and provide evidence that antigen is not essential for the maintenance of CD8(+) T-cell memory. We show that memory CD8(+) cytotoxic T lymphocytes persist indefinitely in the absence of priming antigen, retain the memory phenotype (CD44(hi)), and provide protection against virus challenge. These findings suggest a re-evaluation of our current thinking on mechanisms involved in maintaining immunity and have implications towards designing effective vaccination strategies.