Studies on the effects of a high dose UVA-1 radiation therapy on surface markers and function of epidermal Langerhans cells
Studies on the effects of a high dose UVA-1 radiation therapy on surface markers and function of epidermal Langerhans cells
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高剂量UVA-1放射治疗对表皮朗格汉斯细胞表面标志物和功能影响的研究
DOI：
10.1007/bf00371597
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发表时间：
2004
影响因子：
3
通讯作者：
N. Sönnichsen
中科院分区：
文献类型：
--
作者：
S. Gruner;T. Hofmann;H. Meffert;N. Sönnichsen
最近，高剂量UVA-1治疗（340-400 nm）被引入作为严重加重的特应性皮炎的有效治疗方法。由于这种类型的辐射在皮肤中的目标尚不清楚，我们使用小鼠模型研究了表皮朗格汉斯细胞抗原呈递功能的表面标记是否受到UVA-1辐射的影响。即使重复高剂量的UVA-1辐射（高达50 J/cm2）也没有检测到对朗格汉斯细胞表面atp酶活性和Ia抗原表达的影响。此外，接触性变应原恶唑酮在UVA-1辐射处理的皮肤中表现正常。相比之下，如果在照射前1小时注射8-甲氧基补骨脂素，则观察到朗格汉斯细胞的atp酶活性和Ia抗原表达显著降低，并抑制了对接触敏感性的诱导（PUVA效应）。这些结果表明，表皮朗格汉斯细胞在结构或功能上都没有受损，这些细胞可能不是皮肤中UVA-1辐射的主要目标。高剂量UVA-1治疗不会导致郎格汉斯细胞功能减弱的副作用。
Recently, high-dose UVA-1 therapy (340–400 nm) was introduced as an effective treatment of severe exacerbated atopic dermatitis. Since the target of this type of radiation in the skin is not known we investigated using the mouse model whether surface markers of the antigen-presenting function of epidermal Langerhans cells are affected by UVA-1 radiation. Even repeated high doses of UVA-1 radiation (up to 50 J/cm2) had no detectable effect on surface ATPase activity and Ia antigen expression on Langerhans cells. Also, the contact allergen oxazolone was presented normally in skin treated with UVA-1 radiation. In contrast, if the mice were injected 1 h before irradiation with 8-methoxypsoralen a dramatic reduction in ATPase activity and Ia antigen expression on Langerhans cells was observed and the induction of contact sensitivity was suppressed (PUVA effect). These results show that epidermal Langerhans cells are not impaired either in structure or function and that these cells probably do not represent the primary target of UVA-1 radiation in the skin. No side effects resulting from a diminished Langerhans cell function should result from high-dose UVA-1 therapy.
紫外线 B 辐射将朗格汉斯细胞从免疫原性转化为耐受性抗原呈递细胞。
DOI：
--
发表时间：
1991
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Simon,JC;Tigelaar,RE;Bergstresser,PR;Edelbaum,D;CruzJr,PD
通讯作者：
CruzJr,PD
肿瘤坏死因子-α 和紫外线 B 光对小鼠接触超敏反应具有相似的作用。
DOI：
--
发表时间：
1990
期刊：
Regional immunology
影响因子：
--
作者：
Yoshikawa,T;Streilein,JW
通讯作者：
Streilein,JW