Effect of P2 receptor blockade on cutaneous vasodilation during rest and exercise in the heat in young men
Effect of P2 receptor blockade on cutaneous vasodilation during rest and exercise in the heat in young men
复制标题
P2受体阻断对年轻男性休息和高温运动时皮肤血管舒张的影响
DOI：
10.1139/apnm-2017-0700
复制
发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Kenny Glen P.
中科院分区：
文献类型：
--
作者：
Fujii Naoto;Meade Robert D.;Louie Jeffrey C.;Akbari Pegah;Boulay Pierre;Sigal Ronald J.;Kenny Glen P.
我们评估了嘌呤能P2受体在年轻人静息状态和高温（35 °C）下间歇性中等强度运动时皮肤血管舒张调节中的作用。P2受体阻滞剂增强静息皮肤血管舒张，但在运动期间和运动后没有影响。这种增加部分减少了一氧化氮合酶抑制。这些结果表明，P2受体在调节皮肤血管紧张度在环境中的热暴露在休息的功能作用。
We assessed the role of purinergic P2 receptors in the regulation of cutaneous vasodilation in young adults at rest and during intermittent moderate-intensity exercise in the heat (35 °C). P2 receptor blockade augmented resting cutaneous vasodilation but had no influence during and following exercise. This increase was partly diminished by nitric oxide synthase inhibition. These results suggest a functional role of P2 receptors in the regulation of cutaneous vascular tone during ambient heat exposure at rest.