ESTROGEN-RECEPTOR STATUS - IMPORTANT VARIABLE IN PREDICTING RESPONSE TO ENDOCRINE THERAPY IN METASTATIC BREAST-CANCER
ESTROGEN-RECEPTOR STATUS - IMPORTANT VARIABLE IN PREDICTING RESPONSE TO ENDOCRINE THERAPY IN METASTATIC BREAST-CANCER
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DOI：
10.1016/0014-2964(80)90348-5
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发表时间：
1980-01-01
影响因子：
8.4
通讯作者：
WARREN, R
中科院分区：
文献类型：
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作者：
ALLEGRA, JC;LIPPMAN, ME;WARREN, R
在一项回顾性研究中，确定了85例转移性乳腺癌患者雌激素受体状态对内分泌治疗反应率的影响。根据已知或怀疑影响内分泌治疗反应率的一系列临床变量，评估雌激素受体测定的作用。在52例肿瘤中含有大量雌激素受体（> 10 fmol/mg胞浆蛋白）的患者中，34例对内分泌治疗有客观反应;在33例肿瘤中没有雌激素受体（< 10 fmol/mg胞浆蛋白）的患者中，只有3例有反应（P < 0.0001）。雌激素受体的数量和反应率之间存在定量关系。雌激素受体的数量与反应持续时间无关。雌激素受体测定的预测值与受体解离常数无关。既往接受过内分泌治疗或化疗并没有降低雌激素受体测定预测后续内分泌治疗反应的能力。雌激素受体阳性肿瘤的缓解率不受疾病程度、转移性肿瘤累及部位或既往治疗的影响。在预测内分泌治疗反应方面，这些阴性预后因素的重要性明显低于雌激素受体值。
The influence of estrogen receptor status on response rate to endocrine therapy in 85 patients with metastatic breast cancer was determined in a retrospective study. The role of estrogen receptor determinations in light of a host of clinical variables known or suspected to influence response rates to endocrine therapy was assessed. Of 52 patients whose tumors contained significant amounts of estrogen receptor (> 10 f[femto]mol/mg cytoplasmic protein), 34 had objective responses to endocrine therapy; only 3 of 33 patients whose tumors did not possess estrogen receptor (< 10 fmol/mg cytoplasmic protein) responded (P < 0.0001). A quantitative relationship was found between the amount of estrogen receptor and response rate. The quantity of estrogen receptor was not associated with the duration of response. The predictive value of the estrogen receptor assay was not associated with the receptor dissociation constant. Prior treatment with endocrine or chemotherapy did not diminish the ability of estrogen receptor determinations to predict response to subsequent endocrine therapy. Response rate in estrogen receptor-positive tumors was not affected by extent of disease, site of involvement with metastatic tumor or prior therapy. These negative prognostic factors are apparently less important in predicting response to endocrine therapy than estrogen receptor values.