Temporal coding of visual information in the thalamus
Temporal coding of visual information in the thalamus
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DOI：
10.1523/jneurosci.20-14-05392.2000
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发表时间：
2000-07-15
影响因子：
5.3
通讯作者：
Reid, RC
中科院分区：
文献类型：
--
作者：
Reinagel, P;Reid, RC
感觉神经元携带的有关刺激的信息量直接关系到反应的可靠性。在呈现随机调节的视觉刺激时，我们记录了猫外侧膝状核（LGN）的单个神经元。对重复刺激的反应是可重复的，而来自同一集合的非重复刺激引起的反应是可变的。刺激依赖的信息直接从这些神经反应的熵的差异中量化。我们发现单个LGN细胞可以编码比之前所证明的更多的视觉信息，在我们的细胞样本中可以编码15到102比特/秒的视觉信息。信息速率与细胞放电速率相关，一致的速率为3.6 +/- 0.6 bits/spike（平均+/- SD）。这一信息主要归因于发射概率调制的高时间精度；许多单个尖峰的计时精度优于1毫秒。我们引入了一种方法来估计在发射的时间模式中编码的信息量，这与在任何时间分辨率下随时间变化的发射速率中的信息不同。使用该方法，我们发现时间模式有时会引入冗余，但通常会编码视觉信息。时间模式对响应总信息量的贡献范围为-3.4 ~ -25.5 bits/sec或-9.4 ~ +24.9%。
The amount of information a sensory neuron carries about a stimulus is directly related to response reliability. We recorded from individual neurons in the cat lateral geniculate nucleus (LGN) while presenting randomly modulated visual stimuli. The responses to repeated stimuli were reproducible, whereas the responses evoked by nonrepeated stimuli drawn from the same ensemble were variable. Stimulus-dependent information was quantified directly from the difference in entropy of these neural responses. We show that a single LGN cell can encode much more visual information than had been demonstrated previously, ranging from 15 to 102 bits/sec across our sample of cells. Information rate was correlated with the firing rate of the cell, for a consistent rate of 3.6 +/- 0.6 bits/spike (mean +/- SD). This information can primarily be attributed to the high temporal precision with which firing probability is modulated; many individual spikes were timed with better than 1 msec precision. We introduce a way to estimate the amount of information encoded in temporal patterns of firing, as distinct from the information in the time varying firing rate at any temporal resolution. Using this method, we find that temporal patterns sometimes introduce redundancy but often encode visual information. The contribution of temporal patterns ranged from -3.4 to -25.5 bits/sec or from -9.4 to +24.9% of the total information content of the responses.