Tumor size determines the efficacy of percutaneous ethanol injection for the treatment of small hepatocellular carcinoma
Tumor size determines the efficacy of percutaneous ethanol injection for the treatment of small hepatocellular carcinoma
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DOI：
10.1002/hep.1840160212
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发表时间：
1992-08
期刊：
影响因子：
13.5
通讯作者：
R. Vilana;J. Bruix;C. Brú;C. Ayuso;M. Solé;J. Rodés
中科院分区：
文献类型：
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作者：
R. Vilana;J. Bruix;C. Brú;C. Ayuso;M. Solé;J. Rodés
本研究旨在明确经皮无水乙醇注射治疗小于4 cm的孤立性肝癌的价值。24例肝细胞癌患者（9例Child A、10例Child B和5例Child C）接受了超声引导乙醇注射，这些患者患有不适合手术治疗的肝细胞癌。在4至41个月的随访期间，通过重复超声、计算机断层扫描和肿瘤活检评估其疗效。在5例病例中，在至少12次注射后，乙醇注射未实现完全肿瘤坏死。其余19例病例中有7例最初成功，但在随访期间复发，因此成功率为50%，与基线肿瘤大小显著相关。结节小于2 cm的6例患者获得完全缓解，而肿瘤大小在2 - 3 cm之间的7例患者中有2例获得完全缓解，而在3 - 4 cm之间的11例患者中仅1例获得完全缓解。Child's A和B患者的1年和2年生存率分别为87%和70%。
This study was aimed at defining the therapeutic value of percutaneous ethanol injection in patients with solitary hepatocellular carcinoma less than 4 cm. Ultrasound‐guided ethanol injection was performed in 24 cirrhotic patients (9 Child A, 10 Child B and 5 Child C), with hepatocellular carcinoma not suitable for surgical treatment. Its efficacy was assessed by repeated ultrasound, computed tomography and tumor biopsy during a follow‐up ranging between 4 and 41 mo. Ethanol injection did not achieve a complete tumor necrosis in five cases after a minimum of 12 injections. Seven of the remaining 19 cases, with initial success, have shown recurrence during follow‐up, thus resulting in 50% success rate, which was significantly related to baseline tumor size. The six patients with nodules less than 2 cm achieved a complete response, whereas this was recorded in 2 of the 7 with tumor size between 2 and 3 cm, and in only 1 of the 11 cases between 3 and 4 cm. The 1‐ and 2‐yr survival of Child's A and B patients was 87% and 70%, respectively.