Iridoids from the roots of Valeriana jatamansi and their biological activities
Iridoids from the roots of Valeriana jatamansi and their biological activities
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DOI：
10.1080/14786419.2011.636747
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发表时间：
2012-09
影响因子：
2.2
通讯作者：
Jing Xu;Ping-Xia Guo;Yuanqiang Guo;Lingzhi Fang;Yushan Li;Zhanping Sun;L. Gui
中科院分区：
文献类型：
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作者：
Jing Xu;Ping-Xia Guo;Yuanqiang Guo;Lingzhi Fang;Yushan Li;Zhanping Sun;L. Gui
从蜘蛛香（Valeriana jatamansi）的根中分离得到一个新的环烯醚萜类化合物，即蜘蛛香（Jatamandoid A）（1）和4个已知的类似物（2-5）。通过IR、ESI-MS、HR-ESI-MS、1-D和2-D NMR等波谱分析，确定了化合物的结构。评价了五种化合物，化合物1、2和5显示出对MPP+诱导的神经元SH-SY 5 Y细胞死亡的中等神经保护作用。
A new iridoid, jatamandoid A (1), and four known analogues (2–5) were isolated from the roots of Valeriana jatamansi. Their structures were elucidated on the basis of extensive spectroscopic analysis (IR, ESI–MS, HR–ESI–MS, 1-D and 2-D NMR). Five compounds were evaluated and compounds 1, 2 and 5 showed moderate neuroprotective effects against MPP+-induced neuronal SH-SY5Y cell death.