Cytokines are systemic effectors of lymphatic function in acute inflammation.
Cytokines are systemic effectors of lymphatic function in acute inflammation.
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细胞因子是急性炎症中淋巴功能的全身效应因子。
DOI：
10.1016/j.cyto.2013.05.015
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发表时间：
2013-10
期刊：
影响因子：
3.8
通讯作者：
Sevick-Muraca, Eva M.
中科院分区：
文献类型：
--
作者：
Aldrich, Melissa B.;Sevick-Muraca, Eva M.
The response of the lymphatic system to inflammatory insult and infection is not completely understood. Using a near-infrared fluorescence (NIRF) imaging system to noninvasively document propulsive function, we noted the short-term cessation of murine lymphatic propulsion as early as four hours following LPS injection. Notably, the effects were systemic, displaying bilateral lymphatic pumping cessation after a unilateral insult. Furthermore, IL-1β, TNF-α, and IL-6, cytokines that were found to be elevated in serum during lymphatic pumping cessation, were shown separately to acutely and systemically decrease lymphatic pulsing frequency and velocity following intradermal administration. Surprisingly, marked lymphatic vessel dilation and leakiness were noted in limbs contralateral to IL-1β intradermal administration, but not in ipsilateral limbs. The effects of IL-1β on lymphatic pumping were abated by pretreatment with an inhibitor of inducible nitric oxide synthase, L-NIL (N-iminoethyl-L-lysine). The results suggest that lymphatic propulsion is systemically impaired within four hours of acute inflammatory insult, and that some cytokines are major effectors of lymphatic pumping cessation through nitric oxide-mediated mechanisms. These findings may help in understanding the actions of cytokines as mediators of lymphatic function in inflammatory and infectious states.
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影响因子：
3.1
作者：
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通讯作者：
Majima, Masataka
影响因子：
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作者：
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影响因子：
3.1
作者：
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OBRIG, TG
影响因子：
3.1
作者：
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通讯作者：
BROWN, JF
影响因子：
2.4
作者：
Chakraborty, Sanjukta;Nepiyushchikh, Zhanna;Muthuchamy, Mariappan
通讯作者：
Muthuchamy, Mariappan