Prevalence and Severity of Postdialysis Fatigue Are Higher in Patients on Chronic Hemodialysis With Functional Disability
Prevalence and Severity of Postdialysis Fatigue Are Higher in Patients on Chronic Hemodialysis With Functional Disability
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DOI：
10.1111/1744-9987.12705
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发表时间：
2018-12-01
影响因子：
1.9
通讯作者：
Marzetti, Emanuele
中科院分区：
文献类型：
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作者：
Bossola, Maurizio;Di Stasio, Enrico;Marzetti, Emanuele
本研究的目的是确定慢性血液透析（PCD）伴和不伴功能障碍患者透析后疲劳（PDF）的强度、持续时间、频率和患病率。通过Katz ADL（日常生活活动）问卷和Lawton和Brody量表评估患者的功能能力，使用SF-36活力子量表评估工具性日常生活活动（IADL）疲劳，通过Charlson合并症评分指数（CDI）评估合并症，以及血液透析后恢复时间（TIRD）。我们研究了271个PCD。ADL和IADL残疾分别出现在75例（27.6%）和168例（62%）患者中。ADL残疾患者年龄明显偏大，CDI评分较高，血清白蛋白和Kt/V水平较低。ADL残疾患者的PDF患病率及其严重程度、强度、持续时间和频率均显著较高。IADL残疾的患者年龄较大，CCI评分较高，血清白蛋白和Kt/V水平较低，PDF的严重程度、强度、持续时间和频率较高。在多变量回归分析中，ADL残疾与年龄、PDF的患病率和严重程度以及透析液温度呈正相关，与血清白蛋白水平呈负相关。IADL功能障碍与年龄和透析液温度呈正相关，与血清白蛋白水平呈负相关。总之，PDF的患病率和严重程度显着高于PCD与ADL残疾比那些没有it. This知识的干预措施，以减少PDF的PCD的发展可能有重要意义。
The aim of the present study was to determine the intensity, duration, frequency and prevalence of postdialysis fatigue (PDF) in patients on chronic hemodialysis (PCD) with and without functional disability. Patients underwent assessment of functional ability by the Katz ADL (activity daily living) questionnaire and the Lawton and Brody scale for the instrumental activity daily living (IADL) fatigue using the SF-36 Vitality Subscale, comorbidity through the Charlson comorbidity score index (CDI), and time of recovery after hemodialysis (TIRD). We studied 271 PCD. ADL and IADL disabilities were present in 75 (27.6%) and 168 (62%) patients, respectively. Patients with ADL disability were significantly older and showed higher CDI scores, and lower levels of serum albumin and Kt/V. Prevalence of PDF was significantly higher in patients with ADL disability as well as its severity, intensity, duration and frequency. Patients with IADL disability were significantly older, had a higher CCI score, had lower levels of serum albumin and Kt/V, and had a higher severity, intensity, duration and frequency of PDF. At multivariate regression analysis, ADL disability was positively associated with age, prevalence and severity of PDF, and dialysate temperature and inversely associated with serum albumin levels. IADL disability was instead positively associated with age and dialysate temperature and inversely associated with serum albumin levels. In conclusion, prevalence and severity of PDF are significantly higher in PCD with ADL disability than in those without it. This knowledge may have important implications for the development of interventions to reduce PDF in PCD.