Life and Death Decision-Making by p53 and Implications for Cancer Immunotherapy.
Life and Death Decision-Making by p53 and Implications for Cancer Immunotherapy.
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p53 的生死决策及其对癌症免疫治疗的影响
DOI：
10.1016/j.trecan.2020.10.005
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发表时间：
2021-03
期刊：
影响因子：
18.4
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Liu Y;Leslie PL;Zhang Y
肿瘤抑制因子p53在大约一半的癌症中发生突变，而p53信号网络在几乎所有癌症中都受到干扰。在不同的应激刺激下，p53选择性地激活基因来引发细胞生存或死亡反应。p53如何在生与死之间做出决定仍然是一个引人入胜的问题，也是一个令人兴奋的研究领域。了解这一决定是如何做出的，对改善癌症治疗，特别是最近发展的免疫检查点抑制疗法具有重大意义。在这里，我们强调了在理解p53的生死决策过程的机制方面的进展和挑战，并讨论了该决策如何与免疫系统调节相关。最后，我们讨论了如何将p53促生存和促死亡决策节点的知识应用于优化免疫检查点抑制剂治疗癌症。
The tumor suppressor p53 is mutated in approximately half of all cancers, whereas the p53 signaling network is perturbed in almost all cancers. In response to different stress stimuli, p53 selectively activates genes to elicit a cell survival or cell death response. How p53 makes the decision between life and death remains a fascinating question and an exciting field of research. Understanding how this decision is made has major implications in improving cancer treatments, particularly in recently evolved immune checkpoint inhibition therapy. Here, we highlight progress and challenges in understanding the mechanisms governing p53’s life-and-death decision-making process, and discuss how this decision is relevant to immune system regulation. Finally, we discuss how knowledge of the p53 pro-survival and pro-death decision node can be applied to optimize immune checkpoint inhibitor therapy for cancer treatment.
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影响因子：
64.5
作者：
ELDEIRY, WS;TOKINO, T;VOGELSTEIN, B
通讯作者：
VOGELSTEIN, B
影响因子：
10.3
作者：
Cortez, Maria Angelica;Ivan, Cristina;Welsh, James W.
通讯作者：
Welsh, James W.
影响因子：
11.2
作者：
Banerjee A;Thyagarajan K;Chatterjee S;Chakraborty P;Kesarwani P;Soloshchenko M;Al-Hommrani M;Andrijauskaite K;Moxley K;Janakiraman H;Scheffel MJ;Helke K;Armenson K;Palanisamy V;Rubinstein MP;Mayer EG;Cole DJ;Paulos CM;Christina-Voelkel-Johnson;Nishimura MI;Mehrotra S
通讯作者：
Mehrotra S
DOI：
10.1158/1078-0432.ccr-18-0573
发表时间：
2018-11-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Deniger DC;Pasetto A;Robbins PF;Gartner JJ;Prickett TD;Paria BC;Malekzadeh P;Jia L;Yossef R;Langhan MM;Wunderlich JR;Danforth DN;Somerville RPT;Rosenberg SA
通讯作者：
Rosenberg SA
影响因子：
16.8
作者：
Hafner A;Stewart-Ornstein J;Purvis JE;Forrester WC;Bulyk ML;Lahav G
通讯作者：
Lahav G