Acousto-mechanical and thermal properties of clotted blood
Acousto-mechanical and thermal properties of clotted blood
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DOI：
10.1121/1.2201251
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发表时间：
2006-06-01
影响因子：
2.4
通讯作者：
Holland, Christy K.
中科院分区：
文献类型：
--
作者：
Nahirnyak, Volodymyr M.;Yoon, Suk Wang;Holland, Christy K.
超声辅助溶栓作为缺血性卒中的辅助治疗的有效性正在被广泛研究。为了确定超声热疗在血液凝块破裂过程中的作用，在体外测量了凝块血液的声机械和热特性，即密度、声速、频率依赖性衰减、比热和热导率。在室温（20 +/- 2 ℃）下，测定120 kHz、1.0 MHz和3.5 MHz超声下凝块衰减的幅度系数。猪凝块的衰减系数范围为0.10 - 0.30 Np/cm，人凝块的衰减系数范围为0.09 - 0.23 Np/cm。实验测得猪凝固血的比热和导热系数为（3.2 ± 0.5）× 10 ~（3）J/kg。K和0.55 +/- 0.13 W/m（.）K和人凝血的平均值分别为（3.5 +/- 0.8）× 10（3）J/kg（.）K和0.59 +/- 0.11 W/m（.）K，分别。凝结血液的声机械和热特性的测量可以有助于超声辅助溶栓和其他高强度聚焦超声应用中的超声热疗的理论建模。(c)2006年，美国声学学会。
The efficacy of ultrasound-assisted thrombolysis as an adjunct treatment of ischemic stroke is being widely investigated. To determine the role of ultrasound hyperthermia in the process of blood clot disruption, the acousto-mechanical and thermal properties of clotted blood were measured in vitro, namely, density, speed of sound, frequency-dependent attenuation, specific heat, and thermal conductivity. The amplitude coefficient of attenuation of the clots was determined for 120 kHz, 1.0 MHz, and 3.5 MHz ultrasound at room temperature (20 +/- 2 degrees C). The attenuation coefficient ranged from 0.10 to 0.30 Np/cm in porcine clots and from 0.09 to 0.23 Np/cm in human clots. The experimentally determined values of specific heat and thermal conductivity for porcine clotted blood are (3.2 +/- 0.5) X 10(3) J/kg(.)K and 0.55 +/- 0.13 W/m (.) K, respectively, and for human clotted blood are (3.5 +/- 0.8) X 10(3) J/kg (.) K and 0.59 +/- 0.11 W/m(.)K, respectively. Measurements of the acousto-mechanical and thermal properties of clotted blood can be helpful in theoretical modeling of ultrasound hyperthermia in ultrasound-assisted thrombolysis and other high-intensity focused ultrasound applications. (c) 2006 Acoustical Society of America.