miRDB: an online resource for microRNA target prediction and functional annotations.
miRDB: an online resource for microRNA target prediction and functional annotations.
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DOI：
10.1093/nar/gku1104
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发表时间：
2015-01
影响因子：
14.9
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Wong N;Wang X
microRNAs（miRNAs）是一类非编码小分子RNA，广泛参与多种生理和疾病过程。miRNA研究中的一个主要挑战是鉴定由miRNA调控的基因。为此，我们开发了一个在线资源miRDB（mirdb.org），用于miRNA靶标预测和功能注释。在这里，我们描述了最近更新的miRDB特征，包括由6709个miRNAs调控的210万个预测基因靶点。除了提供预编译的预测数据外，一个新功能是Web服务器界面，允许提交用户提供的序列用于miRNA靶点预测。通过这种方式，用户可以灵活地研究任何定制的miRNA或感兴趣的靶基因。miRDB的另一个主要更新与功能性miRNA注释有关。尽管已经鉴定了数千种miRNAs，但许多报道的miRNAs不太可能发挥积极的功能作用，甚至可能被错误地鉴定为来自高通量研究的miRNAs。为了解决这个问题，我们进行了计算分析和文献挖掘相结合，并确定了568和452个功能的miRNA在人类和小鼠，分别。这些miRNAs以及相关的功能注释，在miRDB的FuncMir Collection中提供。
MicroRNAs (miRNAs) are small non-coding RNAs that are extensively involved in many physiological and disease processes. One major challenge in miRNA studies is the identification of genes regulated by miRNAs. To this end, we have developed an online resource, miRDB (http://mirdb.org), for miRNA target prediction and functional annotations. Here, we describe recently updated features of miRDB, including 2.1 million predicted gene targets regulated by 6709 miRNAs. In addition to presenting precompiled prediction data, a new feature is the web server interface that allows submission of user-provided sequences for miRNA target prediction. In this way, users have the flexibility to study any custom miRNAs or target genes of interest. Another major update of miRDB is related to functional miRNA annotations. Although thousands of miRNAs have been identified, many of the reported miRNAs are not likely to play active functional roles or may even have been falsely identified as miRNAs from high-throughput studies. To address this issue, we have performed combined computational analyses and literature mining, and identified 568 and 452 functional miRNAs in humans and mice, respectively. These miRNAs, as well as associated functional annotations, are presented in the FuncMir Collection in miRDB.
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