Longitudinal Effects of Alcohol Consumption on the Hippocampus and Parahippocampus in College Students
Longitudinal Effects of Alcohol Consumption on the Hippocampus and Parahippocampus in College Students
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DOI：
10.1016/j.bpsc.2018.02.006
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发表时间：
2018-07-01
影响因子：
5.9
通讯作者：
Pearlson, Godfrey D.
中科院分区：
文献类型：
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作者：
Meda, Shashwath A.;Hawkins, Keith A.;Pearlson, Godfrey D.
背景：饮酒对海马体和记忆的有害影响已得到充分证实。然而，乙醇对发育中的大脑的纵向影响以及对记忆的相关后果尚未得到很好的探讨。综上所述，我们研究了大学饮酒对新成年大学生海马体积的纵向影响。方法：数据来源于大学生脑与酒精纵向研究。146名新生（平均基线年龄= 18.5岁）在基线和24个月后接受了脑磁共振成像扫描。使用主成分分析，从每月调查中得出的四项与饮酒有关的措施被简化为单一的酒精使用指数。灰质体积变化（GMV-c）数据采用纵向管道导出。使用SPM12中的多元回归框架，在体向上得出海马/海马旁GMV-c与饮酒指数的关联。评估GMV-c与加州语言学习测试- ii计算的记忆分数之间的补充关联（在研究结束时评估），以及GMV-c与完全酒精引起的记忆丧失之间的补充关联。结果：较大的酒精使用指数与海马/副海马GMV加速下降有关。此外，海马体积下降幅度越大，记忆力越差，记忆力越健忘。结论：我们的研究扩展了之前的横断面文献，表明在大学期间较重的饮酒负担与较大的海马GMV下降有关，而海马GMV下降又与较差的记忆分数有关，所有这些最终都可能对学生的成功产生重大影响。
BACKGROUND: The hazardous effects of alcohol consumption on both the hippocampus and memory have been well established. However, the longitudinal effects of ethanol on the developing brain and related consequences on memory are not well explored. Given the above, we investigated the longitudinal effects of college drinking on hippocampal volume in emerging college adults.METHODS: Data were derived from the longitudinal Brain and Alcohol Research with College Students study. A subset of 146 freshmen (mean age at baseline = 18.5 years) underwent brain magnetic resonance imaging scans at baseline and 24 months later. Four drinking-related measures derived from monthly surveys were reduced to a single alcohol use index using principal component analysis. Gray matter volumetric change (GMV-c) data were derived using a longitudinal pipeline. Voxelwise hippocampal/para-hippocampal GMV-c associations with the drinking index were derived using a multiple regression framework within SPM12. Supplementary associations were assessed between GMV-c and memory scores computed from the California Verbal Learning Test-II (assessed at the end of the study), and between GMV-c and total alcohol-induced memory blackouts.RESULTS: Larger alcohol use index was associated with an accelerated GMV decline in the hippocampus/parahippocampus. Also, larger hippocampal volume decline was associated with poorer memory performance and more memory blackouts.CONCLUSIONS: Our study extends prior cross-sectional literature by showing that a heavier drinking burden while in college is associated with greater hippocampal GMV decline that is in turn associated with poorer memory scores, all of which could ultimately have a significant impact on student success.