Quantitative coronary angiographic studies of patients with angina pectoris and impaired glucose tolerance
Quantitative coronary angiographic studies of patients with angina pectoris and impaired glucose tolerance
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DOI：
10.2337/diacare.28.9.2217
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发表时间：
2005-09-01
期刊：
影响因子：
16.2
通讯作者：
Miyazaki, S
中科院分区：
文献类型：
--
作者：
Kataoka, Y;Yasuda, S;Miyazaki, S
目的：我们使用计算机辅助定量冠状动脉造影术研究糖耐量减低（IGT）患者冠状动脉的形态学特征。IGT是心血管疾病的独立危险因素。然而，IGT患者冠状动脉的形态学变化仍然未知。研究设计和方法-共534例心绞痛患者进行了研究。其中，144名患者正在接受糖尿病治疗。其余390例患者根据75 g口服葡萄糖耐量试验的结果分类如下：正常葡萄糖耐量（NGT）（n = 117）、空腹血糖受损（n = 3）、IGT（n = 136）和糖尿病模式（临床前糖尿病）（n = 134）。测量所有主要冠状动脉段的中段直径并取平均值以确定平均血管直径（AVD）。我们定义了直径为20 mm的节段。结论-弥漫性冠状动脉狭窄不仅发生在糖尿病患者中，也发生在IGT患者中。这种形态学变化与餐后高血糖有关。
OBJECTIVE- We investigated the morphological characteristics of coronary arteries in patients with impaired glucose tolerance (IGT) using computer-assisted quantitative coronary angiography. IGT is an independent risk factor for cardiovascular disease. However, the morphological changes developing in the coronary arteries of patients with IGT remain unknown.RESEARCH DESIGN AND METHODS- A total of 534 patients with angina pectoris were studied. Of these, 144 patients were being treated for diabetes. The remaining 390 patients were classified as follows depending on the results of a 75-g oral glucose tolerance test: normal glucose tolerance (NGT) (n = 117), impaired fasting glucose (n = 3), IGT (n = 136), and diabetes pattern (preclinical diabetes) (n = 134). The diameters of the middle section of all major coronary artery segments were measured and averaged to determine the averaged vessel diameter (AVD). We defined segments of a diameter of 20 mm.CONCLUSIONS- Diffuse coronary artery narrowing develops not only in patients with diabetes but also in those with IGT. This morphological change is associated with postprandial hyperglycemia.