The effects of disease severity, use of corticosteroids and social factors on neuropsychiatric complaints in severe acute respiratory syndrome (SARS) patients at acute and convalescent phases
The effects of disease severity, use of corticosteroids and social factors on neuropsychiatric complaints in severe acute respiratory syndrome (SARS) patients at acute and convalescent phases
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DOI：
10.1016/j.eurpsy.2004.06.023
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发表时间：
2005-05-01
影响因子：
7.8
通讯作者：
Chan, ELY
中科院分区：
文献类型：
--
作者：
Sheng, B;Cheng, SKW;Chan, ELY
Objective. - 评价严重急性呼吸综合征（SARS）患者急性期和恢复期疾病严重程度、皮质类固醇和社会因素对神经精神症状的影响。- 对308例SARS患者出院后进行自填式邮寄问卷调查。对患者及其家属进行神经精神症状调查，包括急性期和恢复期。- 在102例（33%）有效回答中，65%的患者在恢复期出现严重症状，如GHQ 28评分>= 5。多元线性回归分析显示，在急性期使用脉冲类固醇和住院期间脉冲类固醇的总剂量对焦虑抑郁、精神病和行为症状有预测作用，其影响持续到恢复期。疾病严重程度与急性期神经精神各领域症状、恢复期焦虑抑郁和认知功能直接相关。医护人员在这两个阶段有更多的神经精神疾病的投诉。焦虑抑郁症状的严重程度、皮质激素和社会因素在急性期可解释约一半的变异（R-2 = 52），在恢复期可解释约33%的变异。- 严重的疾病，高剂量皮质类固醇和卫生保健工作者是独立的预测神经精神疾病的投诉在急性期和恢复期。(c)2004年，Elsevier SAS。All rights reserved.
Objective. - To evaluate the effects of disease severity, corticosteroids and social factors on neuropsychiatric complaints in severe acute respiratory syndrome (SARS) patients, both during acute and convalescent phases.Subjects and methods. - Self-administered mail questionnaires survey to 308 SARS patients after discharging from hospital. Both patients and their families were asked about symptoms related to various neuropsychiatric domains, and the questions covered both acute and convalescent phases.Results. - Among the 102 (33%) valid replies, 65% had strong symptorns in convalescent phase as indicated by GHQ28 score >= 5. In multiple linear regression analysis, use of pulse steroid and total dosages Of pulse steroid during hospitalisation were predictive for anxiety-depression, psychosis and behavioural symptoms in acute phase, the effects persisted in convalescent phase. Disease severity had direct correlation with symptoms in all neuropsychiatric domains at acute phase and anxiety-depression and cognition at convalescent phase. Health care workers had more neuropsychiatric complaints in both phases. Severity of symptoms, corticosteroids and social factors explained about half of the variances (R-2 = 52) in anxiety-depression at acute phase and 33% at convalescent phase.Conclusion. - Severe disease, high dose corticosteroids and being health care workers were independent predictors of neuropsychiatric complaints in both acute and convalescent phases. (c) 2004 Elsevier SAS. All rights reserved.