AIDS DEMENTIA COMPLEX - EVALUATION WITH PROTON MR SPECTROSCOPIC IMAGING
AIDS DEMENTIA COMPLEX - EVALUATION WITH PROTON MR SPECTROSCOPIC IMAGING
复制标题
DOI：
10.1148/radiology.195.1.7892496
复制
发表时间：
1995-04-01
期刊：
影响因子：
19.7
通讯作者：
MCARTHUR, JC
中科院分区：
文献类型：
--
作者：
BARKER, PB;LEE, RR;MCARTHUR, JC
目的：应用质子磁共振（MR）光谱成像研究获得性免疫缺陷综合征痴呆复合体（ADC）的脑代谢变化，并与常规磁共振成像结果进行比较。材料和方法：7例人类免疫缺陷病毒（HIV）感染的ADC患者（均为男性，年龄33-58岁，平均43岁）和7名年龄匹配的未感染HIV的志愿者进行了光谱和常规MR成像。结果：患者光谱的特征是n -乙酰天冬氨酸水平降低，白质区域胆碱水平升高。在5例脑脊液中检测到乳酸盐。4名轻度至中度痴呆患者比3名只有轻度神经认知改变的患者有更广泛的代谢异常。结论：质子磁共振成像显示了广泛的代谢变化，在检测ADC中枢神经系统受累方面比常规磁共振成像更敏感。
PURPOSE: To investigate cerebral metabolic changes in acquired immunodeficiency syndrome dementia complex (ADC) with proton magnetic resonance (MR) spectroscopic imaging and compare the findings with those of conventional MR imaging.MATERIALS AND METHODS: Seven patients with ADC (all men; age range, 33-58 years; mean, 43 years) with human immunodeficiency virus (HIV) infection and seven age-matched volunteers without HIV infection underwent spectroscopic and conventional MR imaging.RESULTS: Patient spectra were characterized by reduced levels of N-acetyl aspartate and increased levels of choline in white-matter regions. Lactate was detected in the cerebrospinal fluid of five patients. Four patients with mild to moderate dementia had more extensive metabolic abnormalities than three patients with only mild neurocognitive changes.CONCLUSION: Proton MR spectroscopic imaging shows extensive metabolic changes and is more sensitive than conventional MR imaging in the detection of central nervous system involvement in ADC.