The Retinoids : biology, chemistry, and medicine
The Retinoids : biology, chemistry, and medicine
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发表时间：
1994
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通讯作者：
M. Sporn;A. Roberts;D. Goodman
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作者：
M. Sporn;A. Roberts;D. Goodman
简介 Michael B. Sporn 和 Anita B. Roberts 类视黄醇的合成化学 Marcia I. Dawson 和 Peter D. Hobbs 类视黄醇骨架键合方法/构建类视黄醇骨架极地末端的方法 专为辅助生物学研究而设计。分析方法 Harold C. Furr、Arun B. Barua 和 James Allen Olson 生物样品/参考标准/分离方法 其他方法。人类营养中的维生素 A：公共卫生考虑因素 Barbara A. Underwood 历史观点/全球维生素 A 缺乏问题的严重性/亚临床缺乏的眼外健康后果/维生素 A 状况评估。视黄醇和视黄酸代谢 William S. Blaner 和 James Allen Olson 视黄醇的肠道摄取和代谢 / 视黄醇的肝脏代谢和储存 / 肝外组织对视黄醇的摄取、储存和代谢 / 视黄酸的摄取和形成 / 视黄酸的代谢 / 视黄醇的其他代谢物。血浆视黄醇结合蛋白 Dianne Robert Soprano 和 William S. Blaner 视黄醇结合蛋白结构和理化性质 / 视黄醇结合蛋白的分子生物学 / 视黄醇结合蛋白在肝脏和肝外组织中的表达 / 视黄醇结合蛋白的细胞合成和分泌及其调节 / 视黄醇结合蛋白将视黄醇递送至细胞/ 视黄醇结合蛋白与疾病的临床研究和可能的参与。细胞视黄酸结合蛋白 David E. Ong、Marcia E. Newcomer 和 Frank Chytil 发现、细胞视黄酸结合蛋白的初步表征和分布/细胞视黄酸结合蛋白的物理特性/基因结构和表达/功能的调节。类视黄醇受体 David J. Mangelsdorf、Kazuhiko Umesono 和 Ronald M. Evans 类视黄醇受体 / 一种新激素：9-顺式视黄酸 / 靶基因特异性 / 类视黄醇 X 受体异二聚体：激素信号传导的主调节器 / 类视黄醇信号通路中的交叉偶联 / 视黄酸受体和类视黄醇 X 受体表达模式/人类疾病。光敏系统中的类视黄醇 John C. Saari 介绍/视觉过程概述/视觉色素的发色团/光异构化/波长调节视觉周期/视黄醇的细胞摄取。发育中的类视黄醇 Clementine Hofmann 和 Gregor Eichele 类视黄醇和肢体发育/类视黄醇和沿前后体轴的模式/类视黄醇对再生两栖动物肢体的影响。类维生素A 的细胞生物学和生物化学 Lorraine J. Gudas、Michael B. Sporn 和 Anita B. Roberts 类维生素A 基因调节机制概述/类维生素A 对生长因子及其受体活性和合成的影响/类维生素A 对生长因子及其受体活性和合成的影响
lntroduction Michael B. Sporn and Anita B. Roberts The Synthetic Chemistry of Retinoids Marcia I. Dawson and Peter D. Hobbs Retinoid Skeletal-Bond Methodology / Methodology for Constructing the Polar Terminus of the Retinoid Skeleton Retinoids Specifically Designed to Aid Biologic Studies. Analytical Methods Harold C. Furr, Arun B. Barua, and James Allen Olson Biologic Samples / Reference Standards / Separation Methods Other Methods. Vitamin A In Human Nutrition: Public Health Considerations Barbara A. Underwood Historical Perspectives / Magnitude of the Problem of Vitamin A Deficiency Globally / Extraocular Health Consequences of Subclinical Deficiency / Assessment of Vitamin A Status. Retinol and Retinoic Acid Metabolism William S. Blaner and James Allen Olson Intestinal Uptake and Metabolism of Retinol / Hepatic Metabolism and Storage of Retinol / Uptake, Storage, and Metabolism of Retinol by Extrahepatic Tissues / Retinoic Acid Uptake and Formation / Metabolism of Retinoic Acid / Other Metabolites of Retinol. Plasma Retinol-Binding Protein Dianne Robert Soprano and William S. Blaner Retinol-Binding Protein Structure and Physiochemical Properties / The Molecular Biology of Retinol-Binding Protein / The Expression of Retinol-Binding Protein in the Liver and Extrahepatic Tissues / The Cellular Synthesis and Secretion of Retinol-Binding Protein and Its Regulation / Retinol Delivery to Cells by Retinol-Binding Protein / Clinical Studies and Possible Involvement of Retinol-Binding Protein in Disease. Cellular Retinoid-Binding Proteins David E. Ong, Marcia E. Newcomer, and Frank Chytil Discovery, Initial Characterization and Distribution of the Cellular-Retinoid Binding Proteins / Physical Properties of the Cellular-Retinoid Binding Proteins / Gene Structure and Regulation of Expression / Functions. The Retinoid Receptors David J. Mangelsdorf, Kazuhiko Umesono, and Ronald M. Evans Retinoid Receptors / A New Hormone: 9-cis-Retinoic Acid / Target-Gene Specificity / The Retinoid X Receptor Heterodimer: Master Regulator of Hormonal Signalling / Cross-Coupling in Retinoid Signalling Pathways / Retinoic Acid Receptor and Retinoid X Receptor Pattems of Expression / Human Disease. Retinoids In Photosensitive Systems John C. Saari Introduction / Overview of the Visual Process / Chromophores of Visual Pigments /photoisomerisation / Wavelength Regulation The Visual Cycle /Cellular Uptake of Retinol. Retinoids In Development Clementine Hofmann and Gregor Eichele Retinoids and Limb Development / Retinoids and the Pattern Along the Anteroposterior Body Axis / Effects of Retinoids on the Regenerating Amphibian Limb. Cellular Biology and Biochemistry of the Retinoids Lorraine J. Gudas, Michael B. Sporn, and Anita B. Roberts Overview of Mechanisms of Gene Regulation by Retinoids/ Effects of Retinoids on the Activity and Synthesis of Growth Factors and Their Receptors / Effects of Retinoids on the Activity and