LOCUS-COERULEUS NEURONS AND SYMPATHETIC-NERVES - ACTIVATION BY VISCERAL AFFERENTS
LOCUS-COERULEUS NEURONS AND SYMPATHETIC-NERVES - ACTIVATION BY VISCERAL AFFERENTS
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DOI：
10.1016/0006-8993(86)90964-9
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发表时间：
1986-06-04
期刊：
影响因子：
2.9
通讯作者：
SVENSSON, TH
中科院分区：
文献类型：
--
作者：
ELAM, M;THOREN, P;SVENSSON, TH
以前，蓝斑（LC）中的去甲肾上腺素（NE）神经元已被证明对外部环境刺激有深刻的反应，并被认为参与行为功能，如对新刺激，特别是威胁刺激的警觉、警报和焦虑反应。在这里，我们使用电生理技术表明，膀胱、远端结肠、直肠或胃的膨胀引起大鼠大脑NE-LC神经元的明显激活反应，基本上没有伴随内脏、交感神经活动（NE-SNA）的反应，从而表明这些内部刺激的无害特性。我们的发现直接暗示了排尿和排便的LC，我们认为高NE-LC活性可能促进这些阶段性的植物性事件。此外，研究结果表明，LC是自主神经或内脏功能影响行为的关键系统，反过来，环境压力可以影响自主神经功能，例如在阿片类戒断综合征中。
Previously brain norepinephrine (NE) neurons in the locus coeruleus (LC) have been shown to respond profoundly to external, environmental stimuli and are thought to be involved in behavioral functions such as vigilance, alarm and anxiety reactions to novel and, especially, threatening stimuli. Here we have used electrophysiological techniques to show that distension of the urinary bladder, the distal colon, rectum or the stomach causes pronounced activation responses of brain NE-LC neurons of the rat essentially without concomitant responses in splanchnic, sympathetic nerve activity (NE-SNA), thus indicating the non-noxious character of these internal stimuli. Our findings directly implicate the LC in micturition and, probably, defecation and we suggest that a high NE-LC activity may facilitate these phasic, vegetative events. In addition, the results implicate the LC as a pivotal system by which autonomic or visceral functions can affect behavior and, conversely, by which environmental stress can affect autonomic functions, for example in the opiate withdrawal syndrome.