Delayed effects of chronic variable stress during peripubertal-juvenile period on hippocampal morphology and on cognitive and stress axis functions in rats
Delayed effects of chronic variable stress during peripubertal-juvenile period on hippocampal morphology and on cognitive and stress axis functions in rats
复制标题
DOI：
10.1002/hipo.10207
复制
发表时间：
2004-01-01
期刊：
影响因子：
3.5
通讯作者：
Watson, SJ
中科院分区：
文献类型：
--
作者：
Isgor, C;Kabbaj, M;Watson, SJ
在围青春期-青少年时期的慢性可变应激对海马结构和功能的影响的动物研究是缺乏的。28日龄的Sprague-Dawley大鼠进行随机的，可变的身体或社会应激方案4周。海马体积被发现继续增长，在所有层检查过渡到年轻的成年。我们的可变物理应力范例导致抑制这种生长在CA 1锥体细胞层（PCL）和齿状回颗粒细胞层（DG-GCL），达到完全逮捕在CA 3-PCL。容量不足后，首次观察到慢性应激暴露时，3周，但不是24小时，恢复已经过去。此外，这些容量不足与Morris水迷宫导航障碍、基础海马糖皮质激素受体基因表达持续下调以及急性应激诱导的皮质酮分泌关闭缺陷相关。由于正常成熟和慢性应激暴露后的体积变化是独立的神经元数量。因此，一个青春期前后的青少年慢性应激模式，导致显着改变的边缘-下丘脑-垂体-肾上腺轴可以产生强大的影响，海马结构和认知能力，持续到成年。(C)2004 Wiley-Liss，Inc.
Animal studies on the effects of chronic variable stress during the peripubertal-juvenile period on hippocampal structure and function are lacking. Twenty-eight-day-old Sprague-Dawley rats were subjected to random, variable physical or social stress regimens for 4 weeks. Hippocampal volume was found to continue to grow in all lamina examined during the transition into young adulthood. Our variable physical stress paradigm led to inhibition of this growth in the CA1 pyramidal cell layer (PCL) and in the dentate gyrus-granular cell layer (DG-GCL), which reached full arrest in the CA3-PCL. Volume deficits were first observed after chronic stress exposure when 3 weeks, but not 24 h, of recovery had elapsed. Moreover, these volume deficits were associated with impairments in the Morris water-maze navigation, sustained down-regulation in the basal hippocampal glucocorticoid receptor gene expression, and deficits in the shutdown of acute stress-induced corticosterone secretion. Volume changes both due to normal maturation and after chronic stress exposure were independent of neuron number. Thus, a peripubertal-juvenile chronic stress paradigm that leads to significant alterations in the limbic-hypothalamic-pituitary-adrenal axis can produce robust effects in hippocampal structure and cognitive ability, lasting into adulthood. (C) 2004 Wiley-Liss, Inc.