Nationwide survey to compare the prevalence of transient elevation of liver transaminase during treatment of diabetic ketosis or ketoacidosis in new-onset acute and fulminant type 1 diabetes mellitus
Nationwide survey to compare the prevalence of transient elevation of liver transaminase during treatment of diabetic ketosis or ketoacidosis in new-onset acute and fulminant type 1 diabetes mellitus
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DOI：
10.1080/07853890802032711
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发表时间：
2008-01-01
影响因子：
4.4
通讯作者：
Makino, Hideichi
中科院分区：
文献类型：
--
作者：
Takaike, Hiroko;Uchigata, Yasuko;Makino, Hideichi
背景的目标。有时在糖尿病酮症或酮症酸中毒患者中观察到肝酶水平轻度升高。本研究的目的是评估暴发型和急性发作型1型糖尿病患者发生糖尿病酮症或酮症酸中毒时肝脏转氨酶水平升高的原因和流行程度。我们分析了108例18岁以上新诊断的伴有酮症或酮症酸中毒的1型糖尿病患者的肝脏转氨酶水平。数据整理自一项关于暴发性1型糖尿病的全国性调查和回顾性医疗记录。53例暴发性1型糖尿病患者中有32例（60.4%）在开始胰岛素治疗后的第一个月内检测到肝转氨酶（TELT）水平的短暂升高；在急性发作型1型糖尿病的病例中，55例患者中有16例（29.1%）出现了这种观察结果。20%的患者被诊断为脂肪肝，其中65%的患者表现为TELT。这些患者的胰岛素注射剂量明显偏高。高血糖和脂肪肝可能影响新发1型糖尿病治疗过程中肝脏转氨酶水平升高。
Background aims. A mild increase in liver enzyme levels is sometimes observed in patients with diabetic ketosis or ketoacidosis. The aim of the present study was to assess the cause and prevalence of the elevation of liver transaminase levels in fulminant and acute-onset type 1 diabetic patients experiencing diabetic ketosis or ketoacidosis.Methods. We analyzed data on the liver transaminase levels of 108 patients over 18 years of age with newly diagnosed type 1 diabetes complicated by ketosis or ketoacidosis. The data were collated from a nationwide survey on fulminant type 1 diabetes and retrospective medical records.Results. Thirty-two (60.4%) out of the 53 patients suffering from fulminant type 1 diabetes were detected with transient elevation of liver transaminase (TELT) levels during the first month after initiation of insulin therapy; in the case of acute-onset type 1 diabetes, such an observation was noted in 16 (29.1%) out of 55 patients. Fatty liver was diagnosed in 20% of the patients, and 65% of these patients exhibited TELT. The dosage of insulin injected in these patients was significantly high.Conclusions. High blood glucose and fatty liver may influence the elevation of liver transaminase levels during the treatment of new-onset type 1 diabetes.