A test of alcohol dose effects on multiple behavioral measures of impulsivity
A test of alcohol dose effects on multiple behavioral measures of impulsivity
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DOI：
10.1016/j.drugalcdep.2008.02.002
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发表时间：
2008-07-01
影响因子：
4.2
通讯作者：
Mathias, Charles W.
中科院分区：
文献类型：
--
作者：
Dougherty, Donald M.;Marsh-Richard, Dawn M.;Mathias, Charles W.
背景资料：急性酒精管理影响冲动行为，虽然这些影响作为酒精剂量的函数，评估工具，和测量的时间后administration.Methods：我们同时研究了三种不同类型的冲动性任务（连续性能[IMT]，停止信号[GoStop]，延迟折扣[SKIP]任务）的酒精剂量依赖效应。90名健康饮酒者被分配到三个任务组中的一个（每组n = 30），每组在5个实验日内经历安慰剂，0.2，0.4，0.6和0.8 g/kg酒精剂量，并在酒精给药前0.5 h和给药后0.25，1.0和2.0 h评估任务表现。我们假设，随着时间的推移和BrAC峰值期间，急性饮酒会增加所有任务的冲动反应，但幅度取决于所测试的任务。分析包括时间进程和BrAC效应峰值。每个剂量后的峰值行为变化的任务比较说明使用标准化scores.Results：虽然酒精消费增加冲动反应在所有三个任务在一定程度上，我们的假设只有部分支持。在IMT期间，0.6和0.8 g/kg剂量随时间和BrAC峰值产生增加的脉冲反应。然而，在GoStop和SKIP期间，无论酒精剂量大小如何，冲动性都会随着时间的推移而增加，在BrAC峰值时，不同剂量条件下的冲动反应没有差异。结论：这项研究表明，酒精引起的冲动性变化并不均匀地受到酒精的影响。这些数据，结合以前的研究，进一步支持冲动不是一个单一的结构。(C)2008爱思唯尔爱尔兰有限公司保留所有权利。
Background: Acute alcohol administration affects impulsive behavior, although these effects vary as a function of alcohol dose, assessment instrument, and time of measurement following administration.Methods: We concurrently examined the dose-dependent effects of alcohol on three distinct types of impulsivity tasks (continuous performance [IMT], stop-signal [GoStop], and delay-discounting [SKIP] tasks). Ninety healthy alcohol drinkers were assigned to one of the three task groups (n = 30 each), each group experienced placebo, 0.2, 0.4, 0.6, and 0.8 g/kg alcohol doses across 5 experimental days, and task performance was assessed at 0.5 h before and 0.25, 1.0, and 2.0 h after alcohol administration. We hypothesized that impulsive responding on all tasks would be increased by acute alcohol administration both across time and during the peak BrAC, but the magnitude would depend on the task being tested. Analyses included the time course and the peak BrAC effects. Task comparisons of peak behavioral changes following each dose are illustrated using standardized scores.Results: While alcohol consumption increased impulsive responding during all three tasks to some extent, our hypothesis was only partially supported. During the IMT, the 0.6 and 0.8 g/kg doses produced increased impulsive responding across time and at the peak BrAC. However, during the GoStop and SKIP, impulsivity increased across time regardless of the alcohol dose size, with no differences in impulsive responding among dose conditions at peak BrAC.Conclusions: This study demonstrated alcohol-induced changes in impulsivity are not uniformly affected by alcohol. These data, in conjunction with previous studies, further support that impulsivity is not a unitary construct. (C) 2008 Elsevier Ireland Ltd. All rights reserved.