Role of methylglyoxal in Alzheimer's disease.
Role of methylglyoxal in Alzheimer's disease.
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DOI：
10.1155/2014/238485
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发表时间：
2014
影响因子：
--
通讯作者：
Hrelia S
中科院分区：
文献类型：
--
作者：
Angeloni C;Zambonin L;Hrelia S
阿尔茨海默病是最常见和致命的神经退行性疾病。阿尔茨海默病的主要标志是淀粉样β肽的细胞外聚集和存在由过度磷酸化的tau蛋白的沉淀/聚集形成的细胞内神经元缠结。阿尔茨海默病的病因是多因素的，其发病机制的充分理解仍然是难以捉摸的。几年前，有人提出，糖化可能有助于广泛的蛋白质交联和氧化应激在阿尔茨海默病。糖基化是一种内源性过程，导致产生一类称为晚期糖基化终产物（AGEs）的化合物。有趣的是，在阿尔茨海默病患者的大脑中观察到AGEs水平增加。丙酮醛是细胞代谢的活性中间体，是AGEs最有效的前体，与阿尔茨海默病中氧化应激的增加密切相关。许多研究表明，丙酮醛和甲基甘氨酸衍生的AGEs在阿尔茨海默病的发病机制中起着关键作用。
Alzheimer's disease is the most common and lethal neurodegenerative disorder. The major hallmarks of Alzheimer's disease are extracellular aggregation of amyloid β peptides and, the presence of intracellular neurofibrillary tangles formed by precipitation/aggregation of hyperphosphorylated tau protein. The etiology of Alzheimer's disease is multifactorial and a full understanding of its pathogenesis remains elusive. Some years ago, it has been suggested that glycation may contribute to both extensive protein cross-linking and oxidative stress in Alzheimer's disease. Glycation is an endogenous process that leads to the production of a class of compounds known as advanced glycation end products (AGEs). Interestingly, increased levels of AGEs have been observed in brains of Alzheimer's disease patients. Methylglyoxal, a reactive intermediate of cellular metabolism, is the most potent precursor of AGEs and is strictly correlated with an increase of oxidative stress in Alzheimer's disease. Many studies are showing that methylglyoxal and methylglyoxal-derived AGEs play a key role in the etiopathogenesis of Alzheimer's disease.