Association Between BRAFV600E Mutation and the American College of Radiology Thyroid Imaging, Reporting and Data System in Solitary Papillary Thyroid Carcinoma
Association Between BRAFV600E Mutation and the American College of Radiology Thyroid Imaging, Reporting and Data System in Solitary Papillary Thyroid Carcinoma
复制标题
DOI：
10.1016/j.acra.2018.05.010
复制
发表时间：
2019-02-01
影响因子：
4.8
通讯作者：
Li, Peng
中科院分区：
文献类型：
--
作者：
Shangguan, Ronger;Hu, Yuan-Ping;Li, Peng
理由和目的：本研究的目的是评估BRAF（V600E）突变、美国放射学会（ACR）甲状腺成像、报告和数据系统（TI-RADS）对单发甲状腺乳头状癌（PTC）患者超声和临床病理特征的相关性。材料和方法：本回顾性研究包括397例经病理证实的孤立性PTC患者。术后标本采用实时荧光聚合酶链反应检测BRAF（V600E）突变状态。分析BRAF（V600E）突变与ACR TI-RADS及临床病理特征的相关性。结果：在本研究中，BRAF（V600E）突变在孤立性PTC患者中的发生率为81.4%（323/397）。单因素分析显示，BRAF（V600E）突变与切缘、较高的ACR TI-RADS积分和桥本甲状腺炎显著相关。在多变量分析中，分叶或不规则边缘与完全孤立性PTC的BRAF（V600E）突变独立相关。此外，在完全孤立性PTC和乳头状甲状腺微癌中，BRAF（V600E）突变与ACR TI-RADS积分相关，且与BRAF（V600E）突变的风险呈正相关。BRAF（V600E）突变与PTC bbb10 mm ACR TI-RADS积分无显著相关性。此外，桥本的。甲状腺炎与BRAF（V600E）突变呈显著负相关。结论：甲状腺结节分叶状或不规则边缘与PTC患者BRAF（V600E）突变独立相关。此外，较高的ACR TI-RADS积分是BRAF（V600E）突变的独立危险因素，且ACR TI-RADS积分与孤立性PTC，尤其是甲状腺乳头状微癌BRAF（V600E）突变风险呈正相关。我们的研究结果可能有助于BRAF（V600E）突变的PTC患者的术前识别和医疗管理。
Rationale and Objectives: The purpose of this study was to evaluate the associations between BRAF(V600E) mutation, the American College of Radiology (ACR) thyroid imaging, reporting and data system (TI-RADS) on ultrasound and clinicopathological characteristics in patients with a solitary papillary thyroid carcinoma (PTC).Materials and Methods: This retrospective study included 397 patients with a solitary PTC, proved pathologically. BRAF(V600E) mutation status was detected in postoperative samples by real-time fluorescent polymerase chain reaction. Associations of BRAF(V600E) mutation with the ACR TI-RADS and clinico-pathological characteristics were analyzed.Results: In this study, the incidence of BRAF(V600E) mutation was 81.4% (323/397) in patients with a solitary PTC. Univariate analyses showed that BRAF(V600E) mutation was significantly associated with margin, higher ACR TI-RADS point scores, and Hashimoto's thyroiditis. In multivariate analyses, lobulated or irregular margin was independently associated with BRAF(V600E) mutation in total solitary PTC. Furthermore, both in total solitary PTC and papillary thyroid microcarcinoma, BRAF(V600E) mutation was associated with ACR TI-RADS point scores, which was positively correlated with the risk of BRAF(V600E) mutation. There was no significant relationship between BRAF(V600E) mutation and ACR TI-RADS point scores in PTC >10 mm. In addition, Hashimoto's.thyroiclitis had a significant negative association with BRAF(V600E) mutation.Conclusion: A lobulated or irregular margin of the thyroid nodule is independently associated with BRAF(V600E) mutation in patients with PTC. In addition, higher ACR TI-RADS point scores is an independent risk factor for BRAF(V600E) mutation, and ACR TI-RADS point scores is positively associated with the risk of BRAF(V600E) mutation in solitary PTC, especially in papillary thyroid microcarcinoma. Our findings may be helpful for preoperative identification and medical management of PTC patients with BRAF(V600E) mutation.