Imprinting methylation errors in ART
Imprinting methylation errors in ART
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DOI：
10.1007/s12522-014-0183-3
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发表时间：
2014-10-01
影响因子：
3.4
通讯作者：
Arima, Takahiro
中科院分区：
文献类型：
--
作者：
Hiura, Hitoshi;Okae, Hiroaki;Arima, Takahiro
与辅助生殖技术（ART）相关的罕见印迹疾病的发病率报告有所增加。ART，包括体外受精和卵胞浆内精子注射，是育龄不育人群的重要治疗方法，越来越多地产生孩子。ART婴儿印迹位点的表观遗传变化的鉴定表明，ART技术本身可能使胚胎容易获得印迹错误和疾病。在这篇综述中，我们注意到ART的特定步骤可能容易在配子发生、受精和早期胚胎发育过程中诱导印迹甲基化错误。此外，我们还解释了与印记相关的疾病及其原因。此外，从日本全国范围内的印记相关疾病的流行病学研究，我们确定它们与ART的关联。表观遗传学研究将需要了解发病机制，ART相关的风险因素，以及可以采取哪些预防措施来防止输入甲基化错误的发生。我们希望，每一个ART程序后出生的儿童的体质将揭示最安全和最道德的使用方法，这将是宝贵的标准ART的未来发展。
There has been an increase in incidence reports of rare imprinting disorders associated with assisted reproductive technology (ART). ART, including in vitro fertilization and intracytoplasmic sperm injections, is an important treatment for infertile people of reproductive age and increasingly produces children. The identification of epigenetic changes at imprinted loci in ART infants has led to the suggestion that ART techniques themselves may predispose embryos to acquire imprinting errors and diseases. In this review, we note that the particular steps of ART may be prone to induction of imprinting methylation errors during gametogenesis, fertilization and early embryonic development. In addition, we explain imprint-associated diseases and their causes. Moreover, from a Japanese nationwide epidemiological study of imprint-associated diseases, we determine their associations with ART. Epigenetic studies will be required to understand the pathogenesis, ART-related risk factor(s) and what precautions can be taken to prevent the occurrence of input methylation errors. We hope that the constitution of children born after each ART procedure will reveal the safest and most ethical approach to use, which will be invaluable for the future development of standard ART.