Voluntary wheel running ameliorates depression-like behaviors and brain blood oxygen level-dependent signals in chronic unpredictable mild stress mice
Voluntary wheel running ameliorates depression-like behaviors and brain blood oxygen level-dependent signals in chronic unpredictable mild stress mice
复制标题
自愿跑轮可以改善慢性不可预测的轻度应激小鼠的抑郁样行为和脑血氧水平依赖性信号。
DOI：
10.1016/j.bbr.2017.05.032
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发表时间：
2017-07-14
影响因子：
2.7
通讯作者：
Lv, Zhiping
中科院分区：
文献类型：
--
作者：
Huang, Peng;Dong, Zhaoyang;Lv, Zhiping
背景资料：长期以来，体育锻炼对抑郁症的治疗作用一直被认为是有效的，但其潜在的机制仍然很大程度上未知。本研究旨在探讨自愿跑轮运动（VWR）是否改变小鼠抑郁样行为及其对脑血氧水平依赖性（BOLD）信号的影响。方法：成年雄性C57 BL/6小鼠分为以下组：（1）不运动对照组（noEx），饲养在标准笼中;（2）运动（Ex），2 h/d;（3）慢性不可预见的轻度应激（CIMs），模拟成人应激;结果：VWR运动可显著逆转大鼠行为异常。通过对脑功能磁共振低频波动幅度（ALFF）的分析，发现VWR运动可以恢复大脑皮层、海马、胼胝体等边缘系统的BOLD过度激活。此外，VWR运动还可部分减弱BRAS诱导的BOLD抑制区域，如杏仁核、小脑前叶、丘脑、中脑和脑桥。结论：VWR运动可改善抑郁模型小鼠的抑郁样行为和脑内BOLD信号。
Background: Physical exercise has been long recognized for its therapeutic effects on depressive disorders, but the underlying mechanisms remain largely unknown. In the study, we investigated whether the physical exercise by voluntary wheel running (VWR) alters depression-like behaviors and its impact on brain blood oxygen level-dependent (BOLD) signals in mice.Methods: Adult male C57BL/6 mice were assigned to one of the following groups; (1) no exercise control (noEx), housed in a standard cage; (2) exercise (Ex), 2 h/day in a running wheel apparatus; (3) chronic unpredictable mild stress (CUMS), which was imitating adult stress; and (4) CUMS + Ex. The differences in functional brain changes were determined by BOLD functional magnetic resonance imaging (fMRI).Results: The results showed that VWR exercise significantly reversed the CUMS-induced behavioral abnormalities. Base on the fMRI amplitude of low-frequency fluctuation (ALFF) analysis, we found that VWR exercise could restore the CUMS-induced excessive BOLD activation in parts of limbic system, such as cortex, hippocampus and corpus callosum. Furthermore, CUMS-induced BOLD suppressive regions were also partially attenuated by VWR exercise, such as amygdala, cerebellum anterior lobe, thalamus, midbrain, and pontine. Most of these regions are involved in mood-regulating circuit, suggesting dysfunction of the circuit in CUMS model of depression, and VWR exercise could adjust the mood-regulating circuit.Conclusions: These results suggested that VWR exercise ameliorated depression-like behaviors and brain BOLD signals in CUMS induced depression mice.