Asymmetric and symmetric stem-cell divisions in development and cancer
Asymmetric and symmetric stem-cell divisions in development and cancer
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DOI：
10.1038/nature04956
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发表时间：
2006-06-28
期刊：
影响因子：
64.8
通讯作者：
Kimble, Judith
中科院分区：
文献类型：
--
作者：
Morrison, Sean J.;Kimble, Judith
不对称细胞分裂是干细胞的一个决定性特征，这使它们能够同时自我延续（自我更新）并产生分化的后代，这一观点已经被大量研究。然而，许多干细胞可以对称分裂，特别是当它们在发育过程中或受伤后数量增加时。因此，不对称分裂对于干细胞的特性来说并非必要，而是干细胞可以用来维持适当数量后代的一种工具。干细胞对对称或不对称分裂的兼性使用可能是一种关键的适应性，对成年个体的再生能力至关重要。
Much has been made of the idea that asymmetric cell division is a defining characteristic of stem cells that enables them to simultaneously perpetuate themselves (self-renew) and generate differentiated progeny. Yet many stem cells can divide symmetrically, particularly when they are expanding in number during development or after injury. Thus, asymmetric division is not necessary for stem-cell identity but rather is a tool that stem cells can use to maintain appropriate numbers of progeny. The facultative use of symmetric or asymmetric divisions by stem cells may be a key adaptation that is crucial for adult regenerative capacity.