Perceived stress and physiological dysregulation in older adults
Perceived stress and physiological dysregulation in older adults
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DOI：
10.1080/10253890500141905
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发表时间：
2005-06-01
影响因子：
2.3
通讯作者：
Weinstein, M
中科院分区：
文献类型：
--
作者：
Goldman, N;Glei, DA;Weinstein, M
我们使用基于人群的台湾老年人代表性样本来调查受访者感知的压力水平与广泛的生物测量之间的联系。这些生物标志物是在单一时间（2000 年）收集的，反映了交感神经系统 (SNS) 活性、下丘脑-垂体-肾上腺 (HPA) 活性、免疫功能、心血管功能和代谢途径。我们对感知压力与 (1) 16 个单独生物指标中每一个指标的极值之间的关系进行建模； (2) 基于全套生物标志物的累积生理失调测量。我们考虑两种感知压力的衡量标准，一种来自 2000 年的访谈，另一种基于三次访谈（1996-2000 年）的数据。年龄和性别调整模型揭示了感知压力测量值与皮质醇、甘油三酯、白细胞介素 6 (IL-6)、硫酸脱氢表雄酮 (DHEAS) 和空腹血糖极值之间存在显着关联。单独检查后发现，许多生物标志物，包括与血压和肥胖相关的生物标志物，与感知压力没有显着相关。然而，累积的生理克莱斯调节的测量结果与给定时间的感知压力水平和感知压力的纵向测量共同相关。一些结果表明，女性感知压力水平与生理反应之间的关系比男性更强。
We use a population-based representative sample of older Taiwanese to investigate links between respondents' perceived levels of stress and a broad set of biological measures. These biomarkers were collected at a single time (2000) and reflect sympathetic nervous system (SNS)-activity, hypothalamo-pituitary-adrenal (HPA)-activity, immune function, cardiovascular function, and metabolic pathways. We model the relationship between perceived stress and (1) extreme values for each of 16 individual biological indicators; and (2) a measure of cumulative physiological dysregulation based on the full set of biomarkers. We consider two measures of perceived stress, one derived from the 2000 interview and the second based on data from three interviews (1996-2000). Age and sex-adjusted models reveal significant associations between measures of perceived stress and extreme values of cortisol, triglycerides, interleukin-6 (IL-6), dehydroepiandrosterone sulphate (DHEAS) and fasting glucose. Examined individually, numerous biomarkers, including those pertaining to blood pressure and obesity, are not significantly related to perceived stress. jointly, however, the measure of cumulative physiological clysregulation is associated with both the level of perceived stress at a given time and to a longitudinal measure of perceived stress. Some results suggest that the relationship between level of perceived stress and physiological response is stronger for women than men.