Continuous-Flow Synthesis of Monoarylated Acetaldehydes Using Aryldiazonium Salts
Continuous-Flow Synthesis of Monoarylated Acetaldehydes Using Aryldiazonium Salts
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DOI：
10.1021/ja305660a
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发表时间：
2012-08-01
影响因子：
15
通讯作者：
Buchwald, Stephen L.
中科院分区：
文献类型：
--
作者：
Chernyak, Natalia;Buchwald, Stephen L.
苯胺和乙基乙烯基醚可以用作乙醛烯醇化物的α-芳基化的合成等价物的方法的前体。该反应表现出高水平的官能团相容性，允许容易地制备许多有合成价值的化合物。
Anilines and ethyl vinyl ether can be used as precursors for a process that is the synthetic equivalent of the alpha-arylation of acetaldehyde enolate. The reaction manifests a high level of functional group compatibility, allowing the ready preparation of a number of synthetically valuable compounds.