Mitosis controls the Golgi and the Golgi controls mitosis
Mitosis controls the Golgi and the Golgi controls mitosis
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DOI：
10.1016/j.ceb.2007.06.002
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发表时间：
2007-08-01
影响因子：
7.5
通讯作者：
Corda, Daniela
中科院分区：
文献类型：
--
作者：
Colanzi, Antonino;Corda, Daniela
在哺乳动物中，高尔基复合体的结构形式是一个连续的膜系统，由多达100个堆叠组成，由管状桥连接，称为“高尔基带”。在有丝分裂过程中，高尔基体通过一个多阶段的过程经历了广泛的分裂，使其正确的分裂和由子细胞遗传。引人注目的是，这种高尔基断裂不仅对遗传是必需的，而且对有丝分裂进入本身也是必需的，因为它的阻断会导致G2细胞周期的停滞。这被称为“高尔基有丝分裂检查点”。最近的研究已经确定，在G2早期，条带被切断成其组成层，这是控制有丝分裂进入的高尔基断裂的精确阶段。这为阐明高尔基检查点的机制开辟了新的途径。
In mammals, the Golgi complex is structured in the form of a continuous membranous system composed of up to 100 stacks connected by tubular bridges, the 'Golgi ribbon'. During mitosis, the Golgi undergoes extensive fragmentation through a multistage process that allows its correct partitioning and inheritance by daughter cells. Strikingly, this Golgi fragmentation is required not only for inheritance but also for mitotic entrance itself, since its block results in the arrest of the cell cycle in G2. This is called the 'Golgi mitotic checkpoint'. Recent studies have identified the severing of the ribbon into its constituent stacks during early G2 as the precise stage of Golgi fragmentation that controls mitotic entry. This opens new ways to elucidate the mechanism of the Golgi checkpoint.